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The summaries are free for public use. The Chronic Liver Disease Foundation will continue to add and archive summaries of articles deemed relevant to CLDF by the Board of Trustees and its Advisors.

Seladelpar improved measures of pruritus, sleep, and fatigue and decreased serum bile acids in patients with primary biliary cholangitis

Liver Int. 2021 Aug 17. doi: 10.1111/liv.15039. Online ahead of print.

Andreas E Kremer^1 2, Marlyn J Mayo³, Gideon Hirschfield⁴, Cynthia Levy⁵, Christopher L Bowlus⁶, David E Jones⁷, Alexandra Steinberg⁸, Charles A McWherter⁸, Yun-Jung Choi⁸

Liver stiffness measurements by 2-dimensional shear wave elastography compared to histological and ultrasound parameters in primary biliary cholangitis

Scand J Gastroenterol. 2021 Aug 10;1-7.doi: 10.1080/00365521.2021.1928277.Online ahead of print.

Emanuel K Manesis¹, Maria Schina¹, Irene Vafiadis², Ilias Gatos³, John Theotokas³, Pavlos Zoumpoulis³, Peter Drazinos³, John Ketikoglou¹, Ioanna K Delladetsima⁴, Dina G Tiniakos^5 6

The genetic architecture of primary biliary cholangitis

Eur J Med Genet. 2021 Jul 23;64(9):104292. doi: 10.1016/j.ejmg.2021.104292.Online ahead of print.

Alessio Gerussi¹, Marco Carbone², Cristophe Corpechot³, Christoph Schramm⁴, Rosanna Asselta⁵, Pietro Invernizzi⁶

Autoimmune biliary diseases: primary biliary cholangitis and primary sclerosing cholangitis

Pathologica. 2021 Jun;113(3):170-184. doi: 10.32074/1591-951X-245.

Samantha Sarcognato¹, Diana Sacchi¹, Federica Grillo², Nora Cazzagon³, Luca Fabris⁴, Massimiliano Cadamuro⁴, Ivana Cataldo¹, Claudia Covelli⁵, Alessandra Mangia⁶, Maria Guido^1 7

Recent advances in clinical practice: epidemiology of autoimmune liver diseases

Gut. 2021 Jul 15;gutjnl-2020-322362. doi: 10.1136/gutjnl-2020-322362.Online ahead of print.

Palak J Trivedi^1 2 3 4, Gideon M Hirschfield⁵

A consensus integrated care pathway for patients with primary biliary cholangitis: a guideline-based approach to clinical care of patients

Expert Rev Gastroenterol Hepatol. 2021 Jul 7;1-11. doi: 10.1080/17474124.2021.1945919.Online ahead of print.

Gideon M Hirschfield¹, Olivier Chazouillères², Helena Cortez-Pinto³, Guilherme Macedo⁴, Victor de Lédinghen⁵, Femi Adekunle⁶, Marco Carbone⁷

Baricitinib and primary biliary cholangitis

J Transl Autoimmun. 2021 Jun 1;4:100107. doi: 10.1016/j.jtauto.2021.100107. eCollection 2021.

Stuart C Gordon^1 2, Sheri Trudeau³, Arie Regev⁴, Jonathan M Uhas¹, Sujatro Chakladar⁴, Ana Pinto-Correia⁴, Klaus Gottlieb⁴, Doug Schlichting⁴

Obeticholic Acid and Fibrates in Primary Biliary Cholangitis: Comparative Effects in a Multicentric Observational Study

Am J Gastroenterol. 2021 Jun 23. doi: 10.14309/ajg.0000000000001343. Online ahead of print.

Anna Reig^1 2, Carmen Álvarez-Navascués³, Mercedes Vergara^2 4, Elena Gómez-Domínguez⁵, Adolfo Gallego-Moya⁶, Indhira M Pérez-Medrano⁷, Emilio Fábrega⁸, Manuel Hernández-Guerra⁹, Marina Berenguer^2 10 11, Pamela Estevez¹², Ana Arencibia¹³, Rosa M Morillas^2 14, Diana Horta¹⁵, Agustín Albillos^2 16, Marta Casado¹⁷, Gema De la Cruz¹⁸, Eva Fernandez-Bonilla¹⁹, Esther Molina²⁰, Lander Hijona²¹, Moises Diago²², Conrado M Fernández-Rodriguez²³, Jesús M González-Santiago²⁴, Margarita Sala^2 25, Judith Gómez-Camarero²⁶, Manuel Romero-Gomez^2 27, Francisco Suárez²⁸, Victor Vargas^2 29, Carlos Ferre-Aracil³⁰, Raúl J Andrade^2 31, Nadia Chahri³², Albert Parés^1 2

Affi

The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis

Hepatology. 2021 Jun 15. doi: 10.1002/hep.32011. Online ahead of print.

Ben Barron-Millar¹, Laura Ogle¹, George Mells², Steven Flack², Jonathan Badrock², Richard Sandford², John Kirby¹, Jeremy Palmer¹, Laura Jopson¹, John Brain¹, Graham R Smith³, Steve Rushton⁴, Vinod S Hegade⁵, Rebecca Jones⁵, Simon Rushbrook⁶, Douglas Thorburn⁷, Steve Ryder⁸, Gideon Hirschfield^9 10, UK-PBC Research Consortium; Jessica K Dyson^1 11, David Jones^1 11

10.

An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs

Heather J Cordell¹, James J Fryett¹, Kazuko Ueno², Rebecca Darlay¹, Yoshihiro Aiba³, Yuki Hitomi⁴, Minae Kawashima⁴, Nao Nishida⁴, Seik-Soon Khor², Olivier Gervais⁵, Yosuke Kawai², Masao Nagasaki⁵, Katsushi Tokunaga², Ruqi Tang⁶, Yongyong Shi⁷, Zhiqiang Li⁷, Brian D Juran⁸, Elizabeth J Atkinson⁹, Alessio Gerussi¹⁰, Marco Carbone¹⁰, Rosanna Asselta¹¹, Angela Cheung⁸, Mariza de Andrade⁹, Aris Baras¹², Julie Horowitz¹², Manuel A R Ferreira¹², Dylan Sun¹², David E Jones¹³, Steven Flack¹⁴, Ann Spicer¹⁴, Victoria L Mulcahy¹⁴, Jinyoung Byan¹⁵, Younghun Han¹⁵, Richard N Sandford¹⁴, Konstantinos N Lazaridis⁸, Christopher I Amos¹⁵, Gideon M Hirschfield¹⁶, Michael F Seldin¹⁷, Pietro Invernizzi¹⁰, Katherine A Siminovitch¹⁸, Xiong Ma⁶, Minoru Nakamura³, George F Mells¹⁹, Canadian PBC Consortium, Chinese PBC Consortium, Italian PBC Study Group, Japan-PBC-GWAS Consortium, US PBC Consortium, and UK-PBC Consortium

11.

Treatment of primary sclerosing cholangitis

Dig Liver Dis. 2021 May 16;S1590-8658(21)00213-9. doi: 10.1016/j.dld.2021.04.028.Online ahead of print.

Annarosa Floreani¹, Sara De Martin²

12.

Smoking and Liver Disease

Gastroenterol Hepatol (N Y). 2020 Dec;16(12):617-625.

Stephanie M Rutledge¹, Amon Asgharpour

13.

Identification of a Latitude Gradient in the Prevalence of Primary Biliary Cholangitis

Clin Transl Gastroenterol. 2021 May 18;12(5):e00357. doi: 10.14309/ctg.0000000000000357.

Janine French¹, Steve Simpson-Yap^2 3, Ingrid van der Mei³, Justin Ng¹, Peter Angus¹, Paul J Gow¹

14.

Ursodeoxycholic Acid Response Is Associated With Reduced Mortality in Primary Biliary Cholangitis With Compensated Cirrhosis

Am J Gastroenterol. 2021 May 13. doi: 10.14309/ajg.0000000000001280. Online ahead of print.

Binu V John¹, Nidah S Khakoo, Kaley B Schwartz, Gabriella Aitchenson, Cynthia Levy, Bassam Dahman, Yangyang Deng, David S Goldberg, Paul Martin, David E Kaplan, Tamar H Taddei

15.

Detection of anti-mitochondrial 2-oxoacid dehydrogenase complex subunit's antibodies for the diagnosis of primary biliary cholangitis

Clin Immunol. 2021 May 1;108749. doi: 10.1016/j.clim.2021.108749. Online ahead of print.

Elisabet Poyatos¹, Francisco Morandeira², Joan Climent², Virginia Mas², José Castellote³, Jordi Bas²

16.

A Comparison of Prognostic Scores (Mayo, UK-PBC, and GLOBE) in Primary Biliary Cholangitis

Am J Gastroenterol. 2021 May 4. doi: 10.14309/ajg.0000000000001285. Online ahead of print.

Jorn C Goet¹, Carla F Murillo Perez, Maren H Harms, Annarosa Floreani, Nora Cazzagon, Tony Bruns, Florian Prechter, George N Dalekos, Xavier Verhelst, Nikolaos K Gatselis, Keith D Lindor, Willem J Lammers, Aliya Gulamhusein, Anna Reig, Marco Carbone, Frederik Nevens, Gideon M Hirschfield, Adriaan J van der Meer, Henk R van Buuren, Bettina E Hansen, Albert Parés, GLOBAL PBC Study Group

17.

The Management of Cholestatic Liver Diseases: Current Therapies and Emerging New Possibilities

J Clin Med. 2021 Apr 18;10(8):1763. doi: 10.3390/jcm10081763.

Marta Mazzetti^1 2, Giulia Marconi¹, Martina Mancinelli¹, Antonio Benedetti¹, Marco Marzioni¹, Luca Maroni¹

18.

Membranous nephropathy and primary biliary cholangitis: A case report and review of the literature

Clin Nephrol. 2021 Apr 26. doi: 10.5414/CN110363. Online ahead of print.

Jonas Zimmermann, Sigrid Harendza, Mercedes Noriega, Linda Reinhard, Elion Hoxha

19.

Association of bezafibrate with transplant-free survival in patients with primary biliary cholangitis

J Hepatol. 2021 Apr 18;S0168-8278(21)00245-2. doi: 10.1016/j.jhep.2021.04.010.Online ahead of print.

Atsushi Tanaka¹, Junko Hirohara², Toshiaki Nakano², Kosuke Matsumoto³, Olivier Chazouillères⁴, Hajime Takikawa⁵, Bettina E Hansen⁶, Fabrice Carrat⁷, Christophe Corpechot⁸

20.

Short Chain Fatty Acid and Fecal Microbiota Profiles Are Linked to Fibrosis in Primary Biliary Cholangitis

FEMS Microbiol Lett. 2021 Apr 9;fnab038. doi: 10.1093/femsle/fnab038. Online ahead of print.

Craig Lammert¹, Andrea Shin¹, Huiping Xu², Christopher Hemmerich³, Thomas M O'Connell⁴, Naga Chalasani¹

21.

Promyelocytic Leukemia Antigen Expression: a Histological Marker for Primary Biliary Cholangitis Diagnosis?

J Transl Int Med. 2021 Mar 31;9(1):43-51. doi: 10.2478/jtim-2021-0008. eCollection 2021 Mar.

Panagiotis A Papamichalis^1 2, Kalliopi Zachou², Roidoula A Papamichali¹, Maria Ioannou¹, Nikolaos K Gatselis², George N Dalekos², George K Koukoulis¹

22.

Combination of fibrates with obeticholic acid is able to normalise biochemical liver tests in patients with difficult-to-treat primary biliary cholangitis

Aliment Pharmacol Ther. 2021 Mar 25. doi: 10.1111/apt.16336. Online ahead of print.

Pierre-Antoine Soret¹, Laurent Lam¹, Fabrice Carrat¹, Lena Smets², Thomas Berg³, Marco Carbone⁴, Pietro Invernizzi⁴, Vincent Leroy⁵, Palak Trivedi⁶, Nora Cazzagon⁷, Christina Weiler-Normann⁸, Laurent Alric⁹, Isabelle Rosa-Hezode¹⁰, Alexandra Heurgué¹¹, Jean-Paul Cervoni¹², Jérôme Dumortier¹³, Pascal Potier¹⁴, Olivier Roux¹⁵, Christine Silvain¹⁶, Christophe Bureau⁹, Rodolphe Anty¹⁷, Dominique Larrey¹⁸, Cynthia Levy¹⁹, Albert Pares²⁰, Christoph Schramm⁸, Frederik Nevens², Olivier Chazouillères¹, Christophe Corpechot¹

23.

Combination of fibrates with obeticholic acid is able to normalise biochemical liver tests in patients with difficult-to-treat primary biliary cholangitis

Aliment Pharmacol Ther. 2021 Mar 25. doi: 10.1111/apt.16336. Online ahead of print.

24.

Autoimmune Hepatitis-Primary Biliary Cholangitis Overlap Syndrome Triggered by COVID-19

Eur J Case Rep Intern Med. 2021 Feb 4;8(3):002264. doi: 10.12890/2021_002264.eCollection 2021.

Balraj Singh¹, Parminder Kaur², Michael Maroules¹

25.

Safety of fibrates in cholestatic liver diseases

Liver Int. 2021 Mar 9. doi: 10.1111/liv.14871. Online ahead of print.

Andres F Carrion¹, Keith D Lindor², Cynthia Levy³

26.

Accuracy of Transient Elastography in assessing fibrosis at diagnosis in naïve patients with Primary Biliary Cholangitis: a dual cut-off approach

Hepatology. 2021 Mar 16. doi: 10.1002/hep.31810. Online ahead of print.

Laura Cristoferi^1 2 3, Vincenza Calvaruso⁴, Diletta Overi⁵, Mauro Viganò⁶, Cristina Rigamonti⁷, Elisabetta Degasperi⁸, Vincenzo Cardinale⁹, Sara Labanca¹⁰, Nicola Zucchini¹¹, Anna Fichera⁴, Vito Di Marco⁴, Monica Leutner¹², Rosanna Venere¹³, Antonino Picciotto¹⁰, Martina Lucà^1 2, Giacomo Mulinacci^1 2, Andrea Palermo^1 2, Alessio Gerussi^1 2, Daphne D'Amato^1 2, Sarah Elisabeth O'Donnell^1 2, Federica Cerini⁶, Carla De Benedittis⁷, Federica Malinverno^1 2, Vincenzo Ronca^1 2, Clara Mancuso^1 2, Nora Cazzagon¹⁴, Antonio Ciaccio^1 2, Donatella Barisani¹, Marco Marzioni¹⁵, Annarosa Floreani^16 17, Domenico Alvaro⁹, Eugenio Gaudio⁵, Pietro Invernizzi^1 2, Guido Carpino¹⁸, Alessandra Nardi¹⁹, Marco Carbone^1 2, behalf of the Italian PBC Registry

27.

Real-world experience with obeticholic acid in patients with primary biliary cholangitis

JHEP Rep. 2021 Jan 27;3(2):100248. doi: 10.1016/j.jhepr.2021.100248. eCollection 2021 Apr.

Daphne D'Amato¹, Antonio De Vincentis², Federica Malinverno¹, Mauro Viganò³, Domenico Alvaro⁴, Maurizio Pompili⁵, Antonino Picciotto⁶, Valeria Pace Palitti⁷, Maurizio Russello⁸, Silvia Storato⁹, Marie Graciella Pigozzi¹⁰, Vincenza Calvaruso¹¹, Elisabetta De Gasperi¹², Ana Lleo¹³, Antonino Castellaneta¹⁴, Adriano Pellicelli¹⁵, Nora Cazzagon¹⁶, Annarosa Floreani¹⁶, Luigi Muratori¹⁷, Stefano Fagiuoli¹⁸, Grazia Anna Niro¹⁹, Valentina Feletti²⁰, Raffaele Cozzolongo²¹, Natalia Terreni²², Marco Marzioni²³, Rinaldo Pellicano²⁴, Pietro Pozzoni²⁵, Leonardo Baiocchi²⁶, Luchino Chessa²⁷, Floriano Rosina²⁸, Gaetano Bertino²⁹, Maria Vinci³⁰, Anna Morgando²⁴, Ester Vanni²⁴, Gaetano Scifo³¹, Rodolfo Sacco³², Maria D'Antò³³, Valentina Bellia³⁴, Roberto Boldizzoni³⁵, Silvia Casella³⁶, Barbara Omazzi³⁷, Guido Poggi³⁸, Laura Cristoferi¹, Alessio Gerussi¹, Vincenzo Ronca¹, Rosanna Venere⁴, Francesca Ponziani⁵, Maria Cannavò⁸, Alessandro Mussetto²⁰, Rosanna Fontana¹⁹, Francesco Losito²¹, Evelise Frazzetto²⁹, Marco Distefano³¹, Francesca Colapietro¹³, Sara Labanca⁶, Giulia Marconi²³, Giuseppe Grassi²⁶, Giovanni Galati², Sarah Elizabeth O'Donnell¹, Clara Mancuso¹, Giacomo Mulinacci¹, Andrea Palermo¹, Ernesto Claar³⁹, Antonio Izzi⁴⁰, Antonio Picardi², Pietro Invernizzi¹, Marco Carbone¹, Umberto Vespasiani-Gentilucci², Italian PBC Registry and the Club Epatologi Ospedalieri (CLEO)/Associazione Italiana Gastroenterologi ed Endoscopisti Digestivi Ospedalieri (AIGO) PBC Study Group

28.

Home-based exercise in patients with refractory fatigue associated with primary biliary cholangitis: a protocol for the EXerCise Intervention in cholesTatic LivEr Disease (EXCITED) feasibility trial

BMJ Open Gastroenterol. 2021 Mar;8(1):e000579. doi: 10.1136/bmjgast-2020-000579.

Alice Freer^1 2, Felicity Williams^1 3, Simon Durman⁴, Jennifer Hayden², Palak J Trivedi^# 5 2 6, Matthew J Armstrong^# 2

29.

X chromosome contribution to the genetic architecture of primary biliary cholangitis

Gastroenterology. 2021 Mar 3;S0016-5085(21)00466-2. doi: 10.1053/j.gastro.2021.02.061.Online ahead of print.

Rosanna Asselta¹, Elvezia Maria Paraboschi¹, Alessio Gerussi², Heather J Cordell³, George F Mells⁴, Richard N Sandford⁴, David E Jones⁵, Minoru Nakamura⁶, Kazuko Ueno⁷, Yuki Hitomi⁸, Minae Kawashima⁸, Nao Nishida⁸, Katsushi Tokunaga⁹, Masao Nagasaki¹⁰, Atsushi Tanaka¹¹, Ruqi Tang¹², Zhiqiang Li¹³, Yongyong Shi¹³, Xiangdong Liu¹⁴, Ma Xiong¹², Gideon Hirschfield¹⁵, Katherine A Siminovitch¹⁶, Canadian-US PBC Consortium; Italian PBC Genetics Study Group; UK-PBC Consortium; Japan PBC-GWAS Consortium; Marco Carbone², Giulia Cardamone¹, Stefano Duga¹, M Eric Gershwin¹⁷, Michael F Seldin¹⁷, Pietro Invernizzi¹⁸

30.

Quality of life in patients with primary biliary cholangitis: A cross-geographical comparison

J Transl Autoimmun. 2021 Jan 6;4:100081. doi: 10.1016/j.jtauto.2021.100081. eCollection 2021.

Lorenzo Montali¹, Andrea Gragnano¹, Massimo Miglioretti¹, Alessandra Frigerio¹, Luca Vecchio¹, Alessio Gerussi^2 3, Laura Cristoferi^2 3, Vincenzo Ronca^2 3, Daphne D'Amato^2 3, Sarah Elizabeth O'Donnell^2 3, Clara Mancuso^2 3, Martina Lucà^2 3, Minami Yagi⁴, Anna Reig⁵, Laura Jopson⁶, Sesé Pilar⁵, Dave Jones⁶, Albert Pares⁵, George Mells⁷, Atsushi Tanaka⁴, Marco Carbone^2 3, Pietro Invernizzi^2 3

31.

Burden of Primary Biliary Cholangitis Among Inpatient Population in the United States

Hepatol Commun. 2019 Jan 28;3(3):356-364. doi: 10.1002/hep4.1314. eCollection 2019 Mar.

Omer Shahab¹, Mehmet Sayiner¹, James Paik², Sean Felix², Pegah Golabi², Zobair M Younossi^1 2

32.

Investigational drugs in early phase development for primary biliary cholangitis

Expert Opin Investig Drugs. 2021 Feb;30(2):131-141. doi: 10.1080/13543784.2021.1857364.Epub 2020 Dec 11.

Eric M Gochanour¹, Kris V Kowdley¹

33.

Measurement of Gamma Glutamyl Transferase to Determine Risk of Liver Transplantation or Death in Patients With Primary Biliary Cholangitis

Clin Gastroenterol Hepatol. 2020 Aug 7;S1542-3565(20)31083-1.doi: 10.1016/j.cgh.2020.08.006. Online ahead of print.

Alessio Gerussi¹, Davide Paolo Bernasconi², Sarah Elisabeth O'Donnell¹, Willem J Lammers³, Henk Van Buuren³, Gideon Hirschfield⁴, Harry Janssen⁴, Christophe Corpechot⁵, Anna Reig⁶, Albert Pares⁶, Pier Maria Battezzati⁷, Massimo Giovanni Zuin⁷, Nora Cazzagon⁸, Annarosa Floreani⁹, Frederik Nevens¹⁰, Nikolaos Gatselis¹¹, George Dalekos¹¹, Marlyn J Mayo¹², Douglas Thorburn¹³, Tony Bruns¹⁴, Andrew L Mason¹⁵, Xavier Verhelst¹⁶, Kris Kowdley¹⁷, Adriaan van der Meer³, Grazia Anna Niro¹⁸, Benedetta Terziroli Beretta-Piccoli¹⁹, Marco Marzioni²⁰, Luca Saverio Belli²¹, Fabio Marra²², Maria Grazia Valsecchi², Keith D Lindor²³, Pietro Invernizzi¹, Bettina E Hansen²⁴, Marco Carbone²⁵, Italian PBC Study Group and the GLOBAL PBC Study Group

34.

Simplified care-pathway selection for nonspecialist practice: the GLOBAL Primary Biliary Cholangitis Study Group Age, Bilirubin, Alkaline phosphatase risk assessment tool

Eur J Gastroenterol Hepatol. 2020 Dec 14. doi: 10.1097/MEG.0000000000002029.Online ahead of print.

Carla F Murillo Perez^1 2, Aliya Gulamhusein¹, Marco Carbone^3 4, Palak J Trivedi⁵, Adriaan J van der Meer², Christophe Corpechot⁶, Pier Maria Battezzati⁷, Willem J Lammers², Nora Cazzagon^4 8, Annarosa Floreani^4 8, Albert Parés⁹, Frederik Nevens¹⁰, Ana Lleo¹¹, Marlyn J Mayo¹², Kris V Kowdley¹³, Cyriel Y Ponsioen¹⁴, George N Dalekos¹⁵, Nikolaos K Gatselis¹⁵, Douglas Thorburn¹⁶, Andrew L Mason¹⁷, Harry Janssen¹, Xavier Verhelst^4 18, Tony Bruns¹⁹, Keith D Lindor²⁰, Olivier Chazouillères⁶, Pietro Invernizzi^3 4, Bettina E Hansen^1 21, Gideon M Hirschfield¹, GLOBAL PBC Study Group

35.

Utility of palliative EUS-guided biliary drainage using lumen-apposing metal stents: a prospective multicenter feasibility study (with video)

Gastrointest Endosc. 2021 Feb 2;S0016-5107(21)00090-0. doi: 10.1016/j.gie.2021.01.029.Online ahead of print.

Suresh Vasan Venkatachalapathy¹, Martin W James¹, Matthew Huggett², Bharat Paranandi², Stephen P Pereira³, Gavin Johnson⁴, Aloysious D Aravinthan⁵, Guruprasad P Aithal⁵

36.

Is UDCA really a post-transplant panacea?

Liver Transpl. 2021 Jan 19. doi: 10.1002/lt.25989. Online ahead of print.

Cynthia Levy¹, Shahnaz Sultan²

37.

Geo-epidemiology and environmental co-variate mapping of primary biliary cholangitis and primary sclerosing cholangitis

JHEP Rep. 2020 Nov 4;3(1):100202. doi: 10.1016/j.jhepr.2020.100202. eCollection 2021 Feb.

Jessica Katharine Dyson^1 2, Alasdair Blain³, Mark David Foster Shirley⁴, Mark Hudson^1 2, Steven Rushton⁴, David Emrys Jeffreys Jones^1 2

38.

A randomized placebo-controlled trial of elafibranor in patients with primary biliary cholangitis and incomplete response to UDCA

J Hepatol. 2021 Jan 20;S0168-8278(21)00022-2. doi: 10.1016/j.jhep.2021.01.013.Online ahead of print.

Jörn M Schattenberg¹, Albert Pares², Kris V Kowdley³, Michael A Heneghan⁴, Stephen Caldwell⁵, Daniel Pratt⁶, Alan Bonder⁷, Gideon M Hirschfield⁸, Cynthia Levy⁹, John Vierling¹⁰, David Jones¹¹, Anne Tailleux¹², Bart Staels¹², Sophie Megnien¹³, Remy Hanf¹³, David Magrez¹³, Pascal Birman¹³, Velimir Luketic¹⁴

39.

Experimental Pharmacological Agents for the Treatment of Primary Biliary Cholangitis

J Exp Pharmacol. 2020 Dec 17;12:643-652. doi: 10.2147/JEP.S267375.eCollection 2020.

Annarosa Floreani^1 2

40.

Obeticholic acid is associated with improvements in AST-to-platelet ratio index and GLOBE score in patients with primary biliary cholangitis

JHEP Rep. 2020 Sep 29;3(1):100191. doi: 10.1016/j.jhepr.2020.100191. eCollection 2021 Feb.

Maren H Harms¹, Gideon M Hirschfield², Annarosa Floreani³, Marlyn J Mayo⁴, Albert Parés⁵, Alexander Liberman⁶, Elizabeth Smoot Malecha⁶, Richard Pencek⁶, Leigh MacConell⁶, Bettina E Hansen^2 7

41.

Primary biliary cholangitis

Lancet. 2020 Dec 12;396(10266):1915-1926. doi: 10.1016/S0140-6736(20)31607-X.

Ana Lleo¹, Giu-Qiang Wang², Merrill Eric Gershwin³, Gideon M Hirschfield⁴

42.

Portal hypertension in primary biliary cholangitis: prevalence, natural history and histological correlates

Eur J Gastroenterol Hepatol. 2020 Dec 14. doi: 10.1097/MEG.0000000000002033.Online ahead of print.

Thomas W Warnes¹, Stephen A Roberts², Alexander Smith¹, Victor M Cope³, Patricia Vales⁴, Najib Y Haboubi⁵, Raymond F McMahon⁶

43.

UDCA Decreases Incidence of Primary Biliary Cholangitis and Biliary Complications after Liver Transplant: A Meta-Analysis

Liver Transpl. 2020 Nov 13. doi: 10.1002/lt.25935. Online ahead of print.

Mark R Pedersen¹, Garrett Greenan², Sumant Arora³, Arvind Murali³, Marlyn J Mayo¹

44.

Primary Sclerosing Cholangitis and Primary Biliary Cirrhosis Overlap Syndrome: A Review

J Clin Transl Hepatol. 2020 Sep 28;8(3):336-346. doi: 10.14218/JCTH.2020.00036.Epub 2020 Aug 24.

Sheena Mago¹, George Y Wu¹

45.

Fibrates for itch (FITCH) in fibrosing cholangiopathies: a double blind, randomized, placebo-controlled trial

Gastroenterology. 2020 Oct 5;S0016-5085(20)35226-4. doi:10.1053/j.gastro.2020.10.001.Online ahead of print.

Elsemieke de Vries¹, Ruth Bolier¹, Jorn Goet², Albert Parés³, Jef Verbeek⁴, Marleen de Vree⁵, Joost Drenth⁶, Karel van Erpecum⁷, Karin van Nieuwkerk⁸, Frans van der Heide⁵, Nahid Mostafavi¹, Jeltje Helder¹, Cyriel Ponsioen¹, Ronald Oude Elferink¹, Henk van Buuren², Ulrich Beuers⁹, Netherlands Association for the Study of the Liver - Cholestasis Working Group

46.

Genome-wide resolution peripheral blood methylome profiling reveals signatures for cholestatic liver disease

Epigenomics. 2020 Aug;12(16):1363-1375. doi: 10.2217/epi-2020-0048. Epub 2020 Sep 11.

Raymond M Moore¹, Zhifu Sun¹, Brian D Juran², Konstantinos N Lazaridis²

47.

A placebo-controlled randomised trial of budesonide for primary biliary cholangitis following an insufficient response to UDCA

J Hepatol. 2020 Sep 17;S0168-8278(20)33623-0. doi: 10.1016/j.jhep.2020.09.011.Online ahead of print.

G M Hirschfield¹, U Beuers², L Kupcinskas³, P Ott⁴, A Bergquist⁵, M Färkkilä⁶, M P Manns⁷, A Parés⁸, U Spengler⁹, M Stiess¹⁰, R Greinwald¹⁰, M Pröls¹⁰, D Wendum¹¹, U Drebber¹², R Poupon¹³

48.

Liver Stiffness Measured by Either Magnetic Resonance or Transient Elastography Is Associated With Liver Fibrosis and Is an Independent Predictor of Outcomes Among Patients With Primary Biliary Cholangitis

J Clin Gastroenterol. 2020 Sep 23. doi: 10.1097/MCG.0000000000001433. Online ahead of print.

Karim T Osman¹, Daniel B Maselli¹, Ilkay S Idilman², Daniel J Rowan³, Jason K Viehman⁴, William S Harmsen⁴, Denise M Harnois⁵, Elizabeth J Carey⁶, Andrea A Gossard¹, Nicholas F LaRusso¹, Keith D Lindor⁶, Sudhakar K Venkatesh², John E Eaton¹

49.

An update on the management of cholestatic liver diseases

Clin Med (Lond). 2020 Sep;20(5):513-516. doi: 10.7861/clinmed.2020-0697.

Gautham Appanna¹, Yiannis Kallis²

50.

Review article: pathophysiology and management of primary biliary cholangitis

Aliment Pharmacol Ther. 2020 Aug 19. doi: 10.1111/apt.16023. Online ahead of print.

Kristel K Leung^1 2, Maya Deeb^1 2, Gideon M Hirschfield^1 2

51.

Prevalence and long-term outcome of sub-clinical primary sclerosing cholangitis in patients with ulcerative colitis

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Stephen Rice¹, Viviana Albani², Dimitrios Minos³, Gulnar Fattakhova², George F Mells⁴, Marco Carbone⁴, Steven Flack⁴, Nikoletta Varvaropoulou⁴, Jonathan Badrock⁴, Ann Spicer⁴, Richard N Sandford⁴, Mark D F Shirley⁵, Diarmuid Coughlan², Gideon Hirschfield⁶, Simon D Taylor-Robinson⁷, UK-PBC Consortium; Luke Vale², David E J Jones⁸

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Carla F Murillo Perez^1 2, Maren H Harms², Keith D Lindor³, Henk R van Buuren², Gideon M Hirschfield¹, Christophe Corpechot⁴, Adriaan J van der Meer², Jordan J Feld¹, Aliya Gulamhusein¹, Willem J Lammers², Cyriel Y Ponsioen⁵, Marco Carbone⁶, Andrew L Mason⁷, Marlyn J Mayo⁸, Pietro Invernizzi⁶, Pier Maria Battezzati⁹, Annarosa Floreani¹⁰, Ana Lleo¹¹, Frederik Nevens¹², Kris V Kowdley¹³, Tony Bruns^14 15, George N Dalekos¹⁶, Nikolaos K Gatselis¹⁶, Douglas Thorburn¹⁷, Palak J Trivedi¹⁸, Xavier Verhelst¹⁹, Albert Parés²⁰, Harry L A Janssen¹, Bettina E Hansen^1 21, GLOBAL PBC Study Group

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Vinod S Hegade¹, George F Mells², Holly Fisher³, Stuart Kendrick⁴, Julia DiBello⁵, Kim Gilchrist⁵, Graeme J Alexander², Gideon M Hirschfield⁶, Richard N Sandford⁷, David E J Jones⁸, UK-PBC Consortium

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Angela C Cheung¹, Willem J Lammers², Carla F Murillo Perez³, Henk R van Buuren², Aliya Gulamhusein³, Palak J Trivedi⁴, Konstantinos N Lazaridis¹, Cyriel Y Ponsioen⁵, Annarosa Floreani⁶, Gideon M Hirschfield³, Christophe Corpechot⁷, Marlyn J Mayo⁸, Pietro Invernizzi⁹, Pier Maria Battezzati¹⁰, Albert Parés¹¹, Frederik Nevens¹², Douglas Thorburn¹³, Andrew L Mason¹⁴, Marco Carbone⁹, Kris V Kowdley¹⁵, Tony Bruns¹⁶, George N Dalekos¹⁷, Nikolaos K Gatselis¹⁷, Xavier Verhelst¹⁸, Keith D Lindor¹⁹, Ana Lleo⁹, Raoul Poupon⁷, Harry L A Janssen³, Bettina E Hansen²⁰, Global PBC Study Group

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127.	Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease
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128.	Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?
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129.	Trends in the Burden of Non-alcoholic Fatty Liver Disease in a US Cohort of Veterans
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130.	Hepatocellular Carcinoma in the Setting of Non-cirrhotic Nonalcoholic Fatty Liver Disease and the Metabolic Syndrome: US Experience.
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131.	Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis.
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132.	Association of Non-alcoholic Fatty Liver Disease (NAFLD) with Hepatocellular Carcinoma (HCC) in the United States from 2004-2009
	Younossi ZM1,2,3, Otgonsuren M3, Henry L1,3, Venkatesan C2, Mishra A1, Erario M2, Hunt S1. Hepatology. 2015 Aug 14. doi: 10.1002/hep.28123. [Epub ahead of print]

133.	NAFLD Review: Diagnosis, Treatment and Outcomes
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