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The summaries are free for public use. The Chronic Liver Disease Foundation will continue to add and archive summaries of articles deemed relevant to CLDF by the Board of Trustees and its Advisors.

Definition and Management of Patients With Primary Biliary Cholangitis and an Incomplete Response to Therapy

Clin Gastroenterol Hepatol. 2021 Nov;19(11):2241-2251.e1.doi: 10.1016/j.cgh.2020.06.062. Epub 2020 Jul 3.

Aldo J Montano-Loza¹, Christophe Corpechot²

Primary biliary cholangitis has the highest waitlist mortality in patients with cirrhosis and acute on chronic liver failure awaiting liver transplant

Clin Transplant. 2021 Sep 12;e14479. doi: 10.1111/ctr.14479.

Ashwani K Singal^1 2, Robert J Wong³, Rajiv Jalan^4 5, Sumeet Asrani⁶, Yong-Fang Kuo⁷

Incidence of Hepatocellular Carcinoma in Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis

Dig Dis Sci. 2021 Jul;66(7):2439-2451. doi: 10.1007/s10620-020-06498-7.Epub 2020 Aug 2.

Yamini Natarajan¹, Aylin Tansel², Parth Patel², Kingsley Emologu², Richa Shukla², Zeeshan Qureshi², Hashem B El-Serag^2 3 4 5, Aaron P Thrift^2 5, Fasiha Kanwal^2 3 4 5

Cost of illness of Primary Biliary Cholangitis - a population-based study

Dig Liver Dis. 2021 Sep;53(9):1167-1170. doi: 10.1016/j.dld.2020.07.029. Epub 2020 Aug 21.

Alessio Gerussi¹, Umberto Restelli², Davide Croce³, Marzia Bonfanti³, Pietro Invernizzi¹, Marco Carbone⁴

Impact of Obeticholic acid Exposure on Decompensation and Mortality in Primary Biliary Cholangitis and Cirrhosis

Hepatol Commun. 2021 May 6;5(8):1426-1436. doi: 10.1002/hep4.1720. eCollection 2021 Aug.

Binu V John^1 2, Kaley Schwartz¹, Cynthia Levy², Bassam Dahman³, Yangyang Deng³, Paul Martin², Tamar H Taddei^4 5, David E Kaplan^6 7

Long-Term Urinary Copper Excretion on Chelation Therapy in Children with Wilson Disease

J Pediatr Gastroenterol Nutr. 2021 Feb 1;72(2):210-215. doi: 10.1097/MPG.0000000000002982.

Atchariya Chanpong^1 2, Anil Dhawan¹

Male Sex Is Associated With Higher Rates of Liver-Related Mortality in Primary Biliary Cholangitis and Cirrhosis

Hepatology. 2021 Aug;74(2):879-891. doi: 10.1002/hep.31776. Epub 2021 May 26.

Binu V John¹, Gabriella Aitcheson², Kaley B Schwartz¹, Nidah S Khakoo², Bassam Dahman³, Yangyang Deng³, David Goldberg⁴, Paul Martin⁴, Tamar H Taddei^5 6, Cynthia Levy⁴, David E Kaplan^7 8

Understanding Fatigue in Primary Biliary Cholangitis

Dig Dis Sci. 2021 Jul;66(7):2380-2386. doi: 10.1007/s10620-020-06502-0. Epub 2020 Aug 26.

Naw April Phaw^1 2, Jessica Katharine Dyson^1 2, George Mells³, David Jones^4 5

Seladelpar improved measures of pruritus, sleep, and fatigue and decreased serum bile acids in patients with primary biliary cholangitis

Liver Int. 2021 Aug 17. doi: 10.1111/liv.15039. Online ahead of print.

Andreas E Kremer^1 2, Marlyn J Mayo³, Gideon Hirschfield⁴, Cynthia Levy⁵, Christopher L Bowlus⁶, David E Jones⁷, Alexandra Steinberg⁸, Charles A McWherter⁸, Yun-Jung Choi⁸

10.

Liver stiffness measurements by 2-dimensional shear wave elastography compared to histological and ultrasound parameters in primary biliary cholangitis

Scand J Gastroenterol. 2021 Aug 10;1-7.doi: 10.1080/00365521.2021.1928277.Online ahead of print.

Emanuel K Manesis¹, Maria Schina¹, Irene Vafiadis², Ilias Gatos³, John Theotokas³, Pavlos Zoumpoulis³, Peter Drazinos³, John Ketikoglou¹, Ioanna K Delladetsima⁴, Dina G Tiniakos^5 6

11.

The genetic architecture of primary biliary cholangitis

Eur J Med Genet. 2021 Jul 23;64(9):104292. doi: 10.1016/j.ejmg.2021.104292.Online ahead of print.

Alessio Gerussi¹, Marco Carbone², Cristophe Corpechot³, Christoph Schramm⁴, Rosanna Asselta⁵, Pietro Invernizzi⁶

12.

Autoimmune biliary diseases: primary biliary cholangitis and primary sclerosing cholangitis

Pathologica. 2021 Jun;113(3):170-184. doi: 10.32074/1591-951X-245.

Samantha Sarcognato¹, Diana Sacchi¹, Federica Grillo², Nora Cazzagon³, Luca Fabris⁴, Massimiliano Cadamuro⁴, Ivana Cataldo¹, Claudia Covelli⁵, Alessandra Mangia⁶, Maria Guido^1 7

13.

Recent advances in clinical practice: epidemiology of autoimmune liver diseases

Gut. 2021 Jul 15;gutjnl-2020-322362. doi: 10.1136/gutjnl-2020-322362.Online ahead of print.

Palak J Trivedi^1 2 3 4, Gideon M Hirschfield⁵

14.

A consensus integrated care pathway for patients with primary biliary cholangitis: a guideline-based approach to clinical care of patients

Expert Rev Gastroenterol Hepatol. 2021 Jul 7;1-11. doi: 10.1080/17474124.2021.1945919.Online ahead of print.

Gideon M Hirschfield¹, Olivier Chazouillères², Helena Cortez-Pinto³, Guilherme Macedo⁴, Victor de Lédinghen⁵, Femi Adekunle⁶, Marco Carbone⁷

15.

Baricitinib and primary biliary cholangitis

J Transl Autoimmun. 2021 Jun 1;4:100107. doi: 10.1016/j.jtauto.2021.100107. eCollection 2021.

Stuart C Gordon^1 2, Sheri Trudeau³, Arie Regev⁴, Jonathan M Uhas¹, Sujatro Chakladar⁴, Ana Pinto-Correia⁴, Klaus Gottlieb⁴, Doug Schlichting⁴

16.

Obeticholic Acid and Fibrates in Primary Biliary Cholangitis: Comparative Effects in a Multicentric Observational Study

Am J Gastroenterol. 2021 Jun 23. doi: 10.14309/ajg.0000000000001343. Online ahead of print.

Anna Reig^1 2, Carmen Álvarez-Navascués³, Mercedes Vergara^2 4, Elena Gómez-Domínguez⁵, Adolfo Gallego-Moya⁶, Indhira M Pérez-Medrano⁷, Emilio Fábrega⁸, Manuel Hernández-Guerra⁹, Marina Berenguer^2 10 11, Pamela Estevez¹², Ana Arencibia¹³, Rosa M Morillas^2 14, Diana Horta¹⁵, Agustín Albillos^2 16, Marta Casado¹⁷, Gema De la Cruz¹⁸, Eva Fernandez-Bonilla¹⁹, Esther Molina²⁰, Lander Hijona²¹, Moises Diago²², Conrado M Fernández-Rodriguez²³, Jesús M González-Santiago²⁴, Margarita Sala^2 25, Judith Gómez-Camarero²⁶, Manuel Romero-Gomez^2 27, Francisco Suárez²⁸, Victor Vargas^2 29, Carlos Ferre-Aracil³⁰, Raúl J Andrade^2 31, Nadia Chahri³², Albert Parés^1 2

Affi

17.

The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis

Hepatology. 2021 Jun 15. doi: 10.1002/hep.32011. Online ahead of print.

Ben Barron-Millar¹, Laura Ogle¹, George Mells², Steven Flack², Jonathan Badrock², Richard Sandford², John Kirby¹, Jeremy Palmer¹, Laura Jopson¹, John Brain¹, Graham R Smith³, Steve Rushton⁴, Vinod S Hegade⁵, Rebecca Jones⁵, Simon Rushbrook⁶, Douglas Thorburn⁷, Steve Ryder⁸, Gideon Hirschfield^9 10, UK-PBC Research Consortium; Jessica K Dyson^1 11, David Jones^1 11

18.

An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs

Heather J Cordell¹, James J Fryett¹, Kazuko Ueno², Rebecca Darlay¹, Yoshihiro Aiba³, Yuki Hitomi⁴, Minae Kawashima⁴, Nao Nishida⁴, Seik-Soon Khor², Olivier Gervais⁵, Yosuke Kawai², Masao Nagasaki⁵, Katsushi Tokunaga², Ruqi Tang⁶, Yongyong Shi⁷, Zhiqiang Li⁷, Brian D Juran⁸, Elizabeth J Atkinson⁹, Alessio Gerussi¹⁰, Marco Carbone¹⁰, Rosanna Asselta¹¹, Angela Cheung⁸, Mariza de Andrade⁹, Aris Baras¹², Julie Horowitz¹², Manuel A R Ferreira¹², Dylan Sun¹², David E Jones¹³, Steven Flack¹⁴, Ann Spicer¹⁴, Victoria L Mulcahy¹⁴, Jinyoung Byan¹⁵, Younghun Han¹⁵, Richard N Sandford¹⁴, Konstantinos N Lazaridis⁸, Christopher I Amos¹⁵, Gideon M Hirschfield¹⁶, Michael F Seldin¹⁷, Pietro Invernizzi¹⁰, Katherine A Siminovitch¹⁸, Xiong Ma⁶, Minoru Nakamura³, George F Mells¹⁹, Canadian PBC Consortium, Chinese PBC Consortium, Italian PBC Study Group, Japan-PBC-GWAS Consortium, US PBC Consortium, and UK-PBC Consortium

19.

Treatment of primary sclerosing cholangitis

Dig Liver Dis. 2021 May 16;S1590-8658(21)00213-9. doi: 10.1016/j.dld.2021.04.028.Online ahead of print.

Annarosa Floreani¹, Sara De Martin²

20.

Smoking and Liver Disease

Gastroenterol Hepatol (N Y). 2020 Dec;16(12):617-625.

Stephanie M Rutledge¹, Amon Asgharpour

21.

Identification of a Latitude Gradient in the Prevalence of Primary Biliary Cholangitis

Clin Transl Gastroenterol. 2021 May 18;12(5):e00357. doi: 10.14309/ctg.0000000000000357.

Janine French¹, Steve Simpson-Yap^2 3, Ingrid van der Mei³, Justin Ng¹, Peter Angus¹, Paul J Gow¹

22.

Ursodeoxycholic Acid Response Is Associated With Reduced Mortality in Primary Biliary Cholangitis With Compensated Cirrhosis

Am J Gastroenterol. 2021 May 13. doi: 10.14309/ajg.0000000000001280. Online ahead of print.

Binu V John¹, Nidah S Khakoo, Kaley B Schwartz, Gabriella Aitchenson, Cynthia Levy, Bassam Dahman, Yangyang Deng, David S Goldberg, Paul Martin, David E Kaplan, Tamar H Taddei

23.

Detection of anti-mitochondrial 2-oxoacid dehydrogenase complex subunit's antibodies for the diagnosis of primary biliary cholangitis

Clin Immunol. 2021 May 1;108749. doi: 10.1016/j.clim.2021.108749. Online ahead of print.

Elisabet Poyatos¹, Francisco Morandeira², Joan Climent², Virginia Mas², José Castellote³, Jordi Bas²

24.

A Comparison of Prognostic Scores (Mayo, UK-PBC, and GLOBE) in Primary Biliary Cholangitis

Am J Gastroenterol. 2021 May 4. doi: 10.14309/ajg.0000000000001285. Online ahead of print.

Jorn C Goet¹, Carla F Murillo Perez, Maren H Harms, Annarosa Floreani, Nora Cazzagon, Tony Bruns, Florian Prechter, George N Dalekos, Xavier Verhelst, Nikolaos K Gatselis, Keith D Lindor, Willem J Lammers, Aliya Gulamhusein, Anna Reig, Marco Carbone, Frederik Nevens, Gideon M Hirschfield, Adriaan J van der Meer, Henk R van Buuren, Bettina E Hansen, Albert Parés, GLOBAL PBC Study Group

25.

The Management of Cholestatic Liver Diseases: Current Therapies and Emerging New Possibilities

J Clin Med. 2021 Apr 18;10(8):1763. doi: 10.3390/jcm10081763.

Marta Mazzetti^1 2, Giulia Marconi¹, Martina Mancinelli¹, Antonio Benedetti¹, Marco Marzioni¹, Luca Maroni¹

26.

Membranous nephropathy and primary biliary cholangitis: A case report and review of the literature

Clin Nephrol. 2021 Apr 26. doi: 10.5414/CN110363. Online ahead of print.

Jonas Zimmermann, Sigrid Harendza, Mercedes Noriega, Linda Reinhard, Elion Hoxha

27.

Association of bezafibrate with transplant-free survival in patients with primary biliary cholangitis

J Hepatol. 2021 Apr 18;S0168-8278(21)00245-2. doi: 10.1016/j.jhep.2021.04.010.Online ahead of print.

Atsushi Tanaka¹, Junko Hirohara², Toshiaki Nakano², Kosuke Matsumoto³, Olivier Chazouillères⁴, Hajime Takikawa⁵, Bettina E Hansen⁶, Fabrice Carrat⁷, Christophe Corpechot⁸

28.

Short Chain Fatty Acid and Fecal Microbiota Profiles Are Linked to Fibrosis in Primary Biliary Cholangitis

FEMS Microbiol Lett. 2021 Apr 9;fnab038. doi: 10.1093/femsle/fnab038. Online ahead of print.

Craig Lammert¹, Andrea Shin¹, Huiping Xu², Christopher Hemmerich³, Thomas M O'Connell⁴, Naga Chalasani¹

29.

Promyelocytic Leukemia Antigen Expression: a Histological Marker for Primary Biliary Cholangitis Diagnosis?

J Transl Int Med. 2021 Mar 31;9(1):43-51. doi: 10.2478/jtim-2021-0008. eCollection 2021 Mar.

Panagiotis A Papamichalis^1 2, Kalliopi Zachou², Roidoula A Papamichali¹, Maria Ioannou¹, Nikolaos K Gatselis², George N Dalekos², George K Koukoulis¹

30.

Combination of fibrates with obeticholic acid is able to normalise biochemical liver tests in patients with difficult-to-treat primary biliary cholangitis

Aliment Pharmacol Ther. 2021 Mar 25. doi: 10.1111/apt.16336. Online ahead of print.

Pierre-Antoine Soret¹, Laurent Lam¹, Fabrice Carrat¹, Lena Smets², Thomas Berg³, Marco Carbone⁴, Pietro Invernizzi⁴, Vincent Leroy⁵, Palak Trivedi⁶, Nora Cazzagon⁷, Christina Weiler-Normann⁸, Laurent Alric⁹, Isabelle Rosa-Hezode¹⁰, Alexandra Heurgué¹¹, Jean-Paul Cervoni¹², Jérôme Dumortier¹³, Pascal Potier¹⁴, Olivier Roux¹⁵, Christine Silvain¹⁶, Christophe Bureau⁹, Rodolphe Anty¹⁷, Dominique Larrey¹⁸, Cynthia Levy¹⁹, Albert Pares²⁰, Christoph Schramm⁸, Frederik Nevens², Olivier Chazouillères¹, Christophe Corpechot¹

31.

Combination of fibrates with obeticholic acid is able to normalise biochemical liver tests in patients with difficult-to-treat primary biliary cholangitis

Aliment Pharmacol Ther. 2021 Mar 25. doi: 10.1111/apt.16336. Online ahead of print.

32.

Autoimmune Hepatitis-Primary Biliary Cholangitis Overlap Syndrome Triggered by COVID-19

Eur J Case Rep Intern Med. 2021 Feb 4;8(3):002264. doi: 10.12890/2021_002264.eCollection 2021.

Balraj Singh¹, Parminder Kaur², Michael Maroules¹

33.

Safety of fibrates in cholestatic liver diseases

Liver Int. 2021 Mar 9. doi: 10.1111/liv.14871. Online ahead of print.

Andres F Carrion¹, Keith D Lindor², Cynthia Levy³

34.

Accuracy of Transient Elastography in assessing fibrosis at diagnosis in naïve patients with Primary Biliary Cholangitis: a dual cut-off approach

Hepatology. 2021 Mar 16. doi: 10.1002/hep.31810. Online ahead of print.

Laura Cristoferi^1 2 3, Vincenza Calvaruso⁴, Diletta Overi⁵, Mauro Viganò⁶, Cristina Rigamonti⁷, Elisabetta Degasperi⁸, Vincenzo Cardinale⁹, Sara Labanca¹⁰, Nicola Zucchini¹¹, Anna Fichera⁴, Vito Di Marco⁴, Monica Leutner¹², Rosanna Venere¹³, Antonino Picciotto¹⁰, Martina Lucà^1 2, Giacomo Mulinacci^1 2, Andrea Palermo^1 2, Alessio Gerussi^1 2, Daphne D'Amato^1 2, Sarah Elisabeth O'Donnell^1 2, Federica Cerini⁶, Carla De Benedittis⁷, Federica Malinverno^1 2, Vincenzo Ronca^1 2, Clara Mancuso^1 2, Nora Cazzagon¹⁴, Antonio Ciaccio^1 2, Donatella Barisani¹, Marco Marzioni¹⁵, Annarosa Floreani^16 17, Domenico Alvaro⁹, Eugenio Gaudio⁵, Pietro Invernizzi^1 2, Guido Carpino¹⁸, Alessandra Nardi¹⁹, Marco Carbone^1 2, behalf of the Italian PBC Registry

35.

Real-world experience with obeticholic acid in patients with primary biliary cholangitis

JHEP Rep. 2021 Jan 27;3(2):100248. doi: 10.1016/j.jhepr.2021.100248. eCollection 2021 Apr.

Daphne D'Amato¹, Antonio De Vincentis², Federica Malinverno¹, Mauro Viganò³, Domenico Alvaro⁴, Maurizio Pompili⁵, Antonino Picciotto⁶, Valeria Pace Palitti⁷, Maurizio Russello⁸, Silvia Storato⁹, Marie Graciella Pigozzi¹⁰, Vincenza Calvaruso¹¹, Elisabetta De Gasperi¹², Ana Lleo¹³, Antonino Castellaneta¹⁴, Adriano Pellicelli¹⁵, Nora Cazzagon¹⁶, Annarosa Floreani¹⁶, Luigi Muratori¹⁷, Stefano Fagiuoli¹⁸, Grazia Anna Niro¹⁹, Valentina Feletti²⁰, Raffaele Cozzolongo²¹, Natalia Terreni²², Marco Marzioni²³, Rinaldo Pellicano²⁴, Pietro Pozzoni²⁵, Leonardo Baiocchi²⁶, Luchino Chessa²⁷, Floriano Rosina²⁸, Gaetano Bertino²⁹, Maria Vinci³⁰, Anna Morgando²⁴, Ester Vanni²⁴, Gaetano Scifo³¹, Rodolfo Sacco³², Maria D'Antò³³, Valentina Bellia³⁴, Roberto Boldizzoni³⁵, Silvia Casella³⁶, Barbara Omazzi³⁷, Guido Poggi³⁸, Laura Cristoferi¹, Alessio Gerussi¹, Vincenzo Ronca¹, Rosanna Venere⁴, Francesca Ponziani⁵, Maria Cannavò⁸, Alessandro Mussetto²⁰, Rosanna Fontana¹⁹, Francesco Losito²¹, Evelise Frazzetto²⁹, Marco Distefano³¹, Francesca Colapietro¹³, Sara Labanca⁶, Giulia Marconi²³, Giuseppe Grassi²⁶, Giovanni Galati², Sarah Elizabeth O'Donnell¹, Clara Mancuso¹, Giacomo Mulinacci¹, Andrea Palermo¹, Ernesto Claar³⁹, Antonio Izzi⁴⁰, Antonio Picardi², Pietro Invernizzi¹, Marco Carbone¹, Umberto Vespasiani-Gentilucci², Italian PBC Registry and the Club Epatologi Ospedalieri (CLEO)/Associazione Italiana Gastroenterologi ed Endoscopisti Digestivi Ospedalieri (AIGO) PBC Study Group

36.

Home-based exercise in patients with refractory fatigue associated with primary biliary cholangitis: a protocol for the EXerCise Intervention in cholesTatic LivEr Disease (EXCITED) feasibility trial

BMJ Open Gastroenterol. 2021 Mar;8(1):e000579. doi: 10.1136/bmjgast-2020-000579.

Alice Freer^1 2, Felicity Williams^1 3, Simon Durman⁴, Jennifer Hayden², Palak J Trivedi^# 5 2 6, Matthew J Armstrong^# 2

37.

X chromosome contribution to the genetic architecture of primary biliary cholangitis

Gastroenterology. 2021 Mar 3;S0016-5085(21)00466-2. doi: 10.1053/j.gastro.2021.02.061.Online ahead of print.

Rosanna Asselta¹, Elvezia Maria Paraboschi¹, Alessio Gerussi², Heather J Cordell³, George F Mells⁴, Richard N Sandford⁴, David E Jones⁵, Minoru Nakamura⁶, Kazuko Ueno⁷, Yuki Hitomi⁸, Minae Kawashima⁸, Nao Nishida⁸, Katsushi Tokunaga⁹, Masao Nagasaki¹⁰, Atsushi Tanaka¹¹, Ruqi Tang¹², Zhiqiang Li¹³, Yongyong Shi¹³, Xiangdong Liu¹⁴, Ma Xiong¹², Gideon Hirschfield¹⁵, Katherine A Siminovitch¹⁶, Canadian-US PBC Consortium; Italian PBC Genetics Study Group; UK-PBC Consortium; Japan PBC-GWAS Consortium; Marco Carbone², Giulia Cardamone¹, Stefano Duga¹, M Eric Gershwin¹⁷, Michael F Seldin¹⁷, Pietro Invernizzi¹⁸

38.

Quality of life in patients with primary biliary cholangitis: A cross-geographical comparison

J Transl Autoimmun. 2021 Jan 6;4:100081. doi: 10.1016/j.jtauto.2021.100081. eCollection 2021.

Lorenzo Montali¹, Andrea Gragnano¹, Massimo Miglioretti¹, Alessandra Frigerio¹, Luca Vecchio¹, Alessio Gerussi^2 3, Laura Cristoferi^2 3, Vincenzo Ronca^2 3, Daphne D'Amato^2 3, Sarah Elizabeth O'Donnell^2 3, Clara Mancuso^2 3, Martina Lucà^2 3, Minami Yagi⁴, Anna Reig⁵, Laura Jopson⁶, Sesé Pilar⁵, Dave Jones⁶, Albert Pares⁵, George Mells⁷, Atsushi Tanaka⁴, Marco Carbone^2 3, Pietro Invernizzi^2 3

39.

Burden of Primary Biliary Cholangitis Among Inpatient Population in the United States

Hepatol Commun. 2019 Jan 28;3(3):356-364. doi: 10.1002/hep4.1314. eCollection 2019 Mar.

Omer Shahab¹, Mehmet Sayiner¹, James Paik², Sean Felix², Pegah Golabi², Zobair M Younossi^1 2

40.

Investigational drugs in early phase development for primary biliary cholangitis

Expert Opin Investig Drugs. 2021 Feb;30(2):131-141. doi: 10.1080/13543784.2021.1857364.Epub 2020 Dec 11.

Eric M Gochanour¹, Kris V Kowdley¹

41.

Measurement of Gamma Glutamyl Transferase to Determine Risk of Liver Transplantation or Death in Patients With Primary Biliary Cholangitis

Clin Gastroenterol Hepatol. 2020 Aug 7;S1542-3565(20)31083-1.doi: 10.1016/j.cgh.2020.08.006. Online ahead of print.

Alessio Gerussi¹, Davide Paolo Bernasconi², Sarah Elisabeth O'Donnell¹, Willem J Lammers³, Henk Van Buuren³, Gideon Hirschfield⁴, Harry Janssen⁴, Christophe Corpechot⁵, Anna Reig⁶, Albert Pares⁶, Pier Maria Battezzati⁷, Massimo Giovanni Zuin⁷, Nora Cazzagon⁸, Annarosa Floreani⁹, Frederik Nevens¹⁰, Nikolaos Gatselis¹¹, George Dalekos¹¹, Marlyn J Mayo¹², Douglas Thorburn¹³, Tony Bruns¹⁴, Andrew L Mason¹⁵, Xavier Verhelst¹⁶, Kris Kowdley¹⁷, Adriaan van der Meer³, Grazia Anna Niro¹⁸, Benedetta Terziroli Beretta-Piccoli¹⁹, Marco Marzioni²⁰, Luca Saverio Belli²¹, Fabio Marra²², Maria Grazia Valsecchi², Keith D Lindor²³, Pietro Invernizzi¹, Bettina E Hansen²⁴, Marco Carbone²⁵, Italian PBC Study Group and the GLOBAL PBC Study Group

42.

Simplified care-pathway selection for nonspecialist practice: the GLOBAL Primary Biliary Cholangitis Study Group Age, Bilirubin, Alkaline phosphatase risk assessment tool

Eur J Gastroenterol Hepatol. 2020 Dec 14. doi: 10.1097/MEG.0000000000002029.Online ahead of print.

Carla F Murillo Perez^1 2, Aliya Gulamhusein¹, Marco Carbone^3 4, Palak J Trivedi⁵, Adriaan J van der Meer², Christophe Corpechot⁶, Pier Maria Battezzati⁷, Willem J Lammers², Nora Cazzagon^4 8, Annarosa Floreani^4 8, Albert Parés⁹, Frederik Nevens¹⁰, Ana Lleo¹¹, Marlyn J Mayo¹², Kris V Kowdley¹³, Cyriel Y Ponsioen¹⁴, George N Dalekos¹⁵, Nikolaos K Gatselis¹⁵, Douglas Thorburn¹⁶, Andrew L Mason¹⁷, Harry Janssen¹, Xavier Verhelst^4 18, Tony Bruns¹⁹, Keith D Lindor²⁰, Olivier Chazouillères⁶, Pietro Invernizzi^3 4, Bettina E Hansen^1 21, Gideon M Hirschfield¹, GLOBAL PBC Study Group

43.

Utility of palliative EUS-guided biliary drainage using lumen-apposing metal stents: a prospective multicenter feasibility study (with video)

Gastrointest Endosc. 2021 Feb 2;S0016-5107(21)00090-0. doi: 10.1016/j.gie.2021.01.029.Online ahead of print.

Suresh Vasan Venkatachalapathy¹, Martin W James¹, Matthew Huggett², Bharat Paranandi², Stephen P Pereira³, Gavin Johnson⁴, Aloysious D Aravinthan⁵, Guruprasad P Aithal⁵

44.

Is UDCA really a post-transplant panacea?

Liver Transpl. 2021 Jan 19. doi: 10.1002/lt.25989. Online ahead of print.

Cynthia Levy¹, Shahnaz Sultan²

45.

Geo-epidemiology and environmental co-variate mapping of primary biliary cholangitis and primary sclerosing cholangitis

JHEP Rep. 2020 Nov 4;3(1):100202. doi: 10.1016/j.jhepr.2020.100202. eCollection 2021 Feb.

Jessica Katharine Dyson^1 2, Alasdair Blain³, Mark David Foster Shirley⁴, Mark Hudson^1 2, Steven Rushton⁴, David Emrys Jeffreys Jones^1 2

46.

A randomized placebo-controlled trial of elafibranor in patients with primary biliary cholangitis and incomplete response to UDCA

J Hepatol. 2021 Jan 20;S0168-8278(21)00022-2. doi: 10.1016/j.jhep.2021.01.013.Online ahead of print.

Jörn M Schattenberg¹, Albert Pares², Kris V Kowdley³, Michael A Heneghan⁴, Stephen Caldwell⁵, Daniel Pratt⁶, Alan Bonder⁷, Gideon M Hirschfield⁸, Cynthia Levy⁹, John Vierling¹⁰, David Jones¹¹, Anne Tailleux¹², Bart Staels¹², Sophie Megnien¹³, Remy Hanf¹³, David Magrez¹³, Pascal Birman¹³, Velimir Luketic¹⁴

47.

Experimental Pharmacological Agents for the Treatment of Primary Biliary Cholangitis

J Exp Pharmacol. 2020 Dec 17;12:643-652. doi: 10.2147/JEP.S267375.eCollection 2020.

Annarosa Floreani^1 2

48.

Obeticholic acid is associated with improvements in AST-to-platelet ratio index and GLOBE score in patients with primary biliary cholangitis

JHEP Rep. 2020 Sep 29;3(1):100191. doi: 10.1016/j.jhepr.2020.100191. eCollection 2021 Feb.

Maren H Harms¹, Gideon M Hirschfield², Annarosa Floreani³, Marlyn J Mayo⁴, Albert Parés⁵, Alexander Liberman⁶, Elizabeth Smoot Malecha⁶, Richard Pencek⁶, Leigh MacConell⁶, Bettina E Hansen^2 7

49.

Primary biliary cholangitis

Lancet. 2020 Dec 12;396(10266):1915-1926. doi: 10.1016/S0140-6736(20)31607-X.

Ana Lleo¹, Giu-Qiang Wang², Merrill Eric Gershwin³, Gideon M Hirschfield⁴

50.

Portal hypertension in primary biliary cholangitis: prevalence, natural history and histological correlates

Eur J Gastroenterol Hepatol. 2020 Dec 14. doi: 10.1097/MEG.0000000000002033.Online ahead of print.

Thomas W Warnes¹, Stephen A Roberts², Alexander Smith¹, Victor M Cope³, Patricia Vales⁴, Najib Y Haboubi⁵, Raymond F McMahon⁶

51.

UDCA Decreases Incidence of Primary Biliary Cholangitis and Biliary Complications after Liver Transplant: A Meta-Analysis

Liver Transpl. 2020 Nov 13. doi: 10.1002/lt.25935. Online ahead of print.

Mark R Pedersen¹, Garrett Greenan², Sumant Arora³, Arvind Murali³, Marlyn J Mayo¹

52.

Primary Sclerosing Cholangitis and Primary Biliary Cirrhosis Overlap Syndrome: A Review

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M Cauldwell¹, F L Mackie², P J Steer¹, M A Henehghan³, J H Baalman⁴, J Brennand⁵, T Johnston², S Dockree⁶, C Hedley⁷, S Jarvis⁸, S Khan⁹, F M McAuliffe⁴, L Mackillop⁶, L Penna⁷, B Smith¹⁰, P Trivedi⁹, S Verma^11 12, R Westbrook¹³, S Winifield¹⁴, C Williamson¹⁵

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125.	The Gut Microbiota and Nonalcoholic Fatty Liver Disease
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126.	Systemic Complications of Nonalcoholic Fatty Liver Disease: When the Liver Is Not an Innocent Bystander
	Vanni E1, Marengo A1, Mezzabotta L1, Bugianesi E1. Semin Liver Dis. 2015 Aug;35(3):236-49. doi: 10.1055/s-0035-1562944. Epub 2015 Sep 17.

127.	Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability
	Luther J1, Garber JJ1, Khalili H1, Dave M2, Bale SS3, Jindal R3, Motola DL1, Luther S1, Bohr S3, Jeoung SW1, Deshpande V1, Singh G4, Turner JR4, Yarmush ML3, Chung RT1, Patel SJ3. Cell Mol Gastroenterol Hepatol. 2015 Mar;1(2):222-232.

128.	The Prevalence and Presumed Etiology of Elevated Aminotransferase Levels in a Pacific Northwest Tribal Community
	Scott J, Kowdley KV, Ioannou GN, Krantz E, Lallemand O, Tsosie U, Buchwald D. J Health Care Poor Underserved. 2015;26(3):957-66. doi: 10.1353/hpu.2015.0091.

129.	Burden of nonalcoholic fatty liver disease and advanced fibrosis in a Texas Hispanic community cohort
	Pan JJ1, Fisher-Hoch SP1, Chen C1, Feldstein AE1, McCormick JB1, Rahbar MH1, Beretta L1, Fallon MB1. World J Hepatol. 2015 Jun 18;7(11):1586-94. doi: 10.4254/wjh.v7.i11.1586.

130.	Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease
	Pacana T1, Cazanave S1, Verdianelli A1, Patel V1, Min HK1, Mirshahi F1, Quinlivan E2, Sanyal AJ1. PLoS One. 2015 Aug 31;10(8):e0136822. doi: 10.1371/journal.pone.0136822. eCollection 2015.

131.	Cost-Effective Evaluation of Nonalcoholic Fatty Liver Disease With NAFLD Fibrosis Score and Vibration Controlled Transient Elastography
	Tapper EB1, Sengupta N1, Hunink MG2,3, Afdhal NH1, Lai M1. Am J Gastroenterol. 2015 Sep;110(9):1298-304. doi: 10.1038/ajg.2015.241. Epub 2015 Aug 25.

132.	Nonmedicinal interventions in nonalcoholic fatty liver disease
	Neuman MG, Nanau RM, Cohen LB. Can J Gastroenterol Hepatol. 2015 Jun-Jul;29(5):241-52.

133.	Non-alcoholic fatty liver disease following liver transplantation: a clinical review
	Merola J1, Liapakis A2, Mulligan DC1, Yoo PS1. Clin Transplant. 2015 Sep;29(9):728-37. doi: 10.1111/ctr.12585. Epub 2015 Aug 11.

134.	Vitamin E has a beneficial effect on nonalcoholic fatty liver disease: a meta-analysis of randomized controlled trials
	Sato K1, Gosho M2, Yamamoto T3, Kobayashi Y3, Ishii N3, Ohashi T3, Nakade Y3, Ito K3, Fukuzawa Y3, Yoneda M3. Nutrition. 2015 Jul-Aug;31(7-8):923-30. doi: 10.1016/j.nut.2014.11.018. Epub 2014 Dec 24.

135.	Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease
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136.	Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?
	Kohli R1, Myronovych A, Tan BK, Salazar-Gonzalez RM, Miles L, Zhang W, Oehrle M, Sandoval DA, Ryan KK, Seeley RJ, Setchell KD. Dig Dis. 2015;33(3):440-6. doi: 10.1159/000371699. Epub 2015 May 27.

137.	Trends in the Burden of Non-alcoholic Fatty Liver Disease in a US Cohort of Veterans
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138.	Hepatocellular Carcinoma in the Setting of Non-cirrhotic Nonalcoholic Fatty Liver Disease and the Metabolic Syndrome: US Experience.
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139.	Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis.
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140.	Association of Non-alcoholic Fatty Liver Disease (NAFLD) with Hepatocellular Carcinoma (HCC) in the United States from 2004-2009
	Younossi ZM1,2,3, Otgonsuren M3, Henry L1,3, Venkatesan C2, Mishra A1, Erario M2, Hunt S1. Hepatology. 2015 Aug 14. doi: 10.1002/hep.28123. [Epub ahead of print]

141.	NAFLD Review: Diagnosis, Treatment and Outcomes
	Ahmed A1, Wong RJ2, Harrison SA3. Clin Gastroenterol Hepatol. 2015 Jul 27. pii: S1542-3565(15)00988-X. doi: 10.1016/j.cgh.2015.07.029. [Epub ahead of print]

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