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NASH | Abstract Library

The summaries are free for public use. The Chronic Liver Disease Foundation will continue to add and archive summaries of articles deemed relevant to CLDF by the Board of Trustees and its Advisors.

1.	The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease
	Romero FA, Jones C, Xu Y, Fenaux M, Halcomb RL. J Med Chem. 2020 Jan 13. doi: 10.1021/acs.jmedchem.9b01701. [Epub ahead of print]

2.	A Model to Identify Heavy Drinkers at High Risk for Liver Disease Progression
	Delacôte C¹, Bauvin P¹, Louvet A², Dautrecque F³, Ntandja Wandji LC³, Lassailly G², Voican C⁴, Perlemuter G⁴, Naveau S⁴, Mathurin P², Deuffic-Burban S⁵. Clin Gastroenterol Hepatol. 2020 Jan 10. pii: S1542-3565(20)30039-2. doi: 10.1016/j.cgh.2019.12.041. [Epub ahead of print]

3.	Small but mighty: Platelets in NASH and other chronic liver diseases
	Hilscher MB¹, Shah VH¹. Hepatology. 2020 Jan 5. doi: 10.1002/hep.31101. [Epub ahead of print]

4.	Continued muscle loss increases mortality in cirrhosis- impact of etiology of liver disease
	Welch N^1,2, Dasarathy J³, Runkana A⁴, Penumatsa R², Bellar A², Reen J², Rotroff D⁵, McCullough AJ¹, Dasarathy S^1,2. Liver Int. 2019 Dec 31. doi: 10.1111/liv.14358. [Epub ahead of print]

5.	Childhood and Adolescent Nonalcoholic Fatty Liver Disease: Is It Different from Adults?
	Fitzpatrick E¹, Dhawan A¹. J Clin Exp Hepatol. 2019 Nov-Dec;9(6):716-722. doi: 10.1016/j.jceh.2019.05.005. Epub 2019 May 31.

6.	Carotenoids and fatty liver disease: Current knowledge and research gaps
	Clugston RD¹. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jan 2:158597. doi: 10.1016/j.bbalip.2019.158597. [Epub ahead of print]

7.	Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression
	Du K¹, Chitneni SK², Suzuki A¹, Wang Y¹, Henao R³, Hyun J¹, Premont RT¹, Naggie S⁴, Moylan CA¹, Bashir MR⁵, Abdelmalek MF¹, Diehl AM⁶. Cell Mol Gastroenterol Hepatol. 2019 Dec 24. pii: S2352-345X(19)30182-1. doi: 10.1016/j.jcmgh.2019.12.006. [Epub ahead of print]

A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis

Harrison SA¹, Goodman Z², Jabbar A³, Vemulapalli R⁴, Younes ZH⁵, Freilich B⁶, Sheikh MY⁷, Schattenberg JM⁸, Kayali Z⁹, Zivony A¹⁰, Sheikh A¹¹, Garcia-Samaniego J¹², Satapathy SK¹³, Therapondos G¹⁴, Mena E¹⁵, Schuppan D¹⁶, Robinson J¹⁷, Chan JL¹⁷, Hagerty DT¹⁸, Sanyal AJ¹⁹. J Hepatol. 2019 Dec 27. pii: S0168-8278(19)30758-5. doi: 10.1016/j.jhep.2019.11.024. [Epub ahead of print]

9.	A Pilot Genome-Wide Analysis Study Identifies Loci Associated With Response to Obeticholic Acid in Patients With NASH
	Gawrieh S¹, Guo X², Tan J², Lauzon M², Taylor KD², Loomba R³, Cummings OW⁴, Pillai S⁵, Bhatnagar P⁵, Kowdley KV⁶, Yates K⁷, Wilson LA⁷, Chen YI², Rotter JI², Chalasani N¹; NASH Clinical Research Network. Hepatol Commun. 2019 Nov 3;3(12):1571-1584. doi: 10.1002/hep4.1439. eCollection 2019 Dec.

10.	Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review
	Saeed N¹, Nadeau B¹, Shannon C², Tincopa M¹. Nutrients. 2019 Dec 16;11(12). pii: E3064. doi: 10.3390/nu11123064.

11.	Nonalcoholic Fatty Liver Disease and Fibrosis Associated With Increased Risk of Cardiovascular Events in a Prospective Study
	Baratta F¹, Pastori D², Angelico F³, Balla A⁴, Paganini AM⁴, Cocomello N¹, Ferro D¹, Violi F⁵, Sanyal AJ⁶, Del Ben M¹. Clin Gastroenterol Hepatol. 2019 Dec 27. pii: S1542-3565(19)31506-X. doi: 10.1016/j.cgh.2019.12.026. [Epub ahead of print]

12.	When the Liver Gets Stiff, the Tough Get Moving
	Nguyen TH¹, Wardell R¹, Chitturi S¹, Teoh N¹, Farrell G^1,2. J Gastroenterol Hepatol. 2019 Dec 22. doi: 10.1111/jgh.14963. [Epub ahead of print]

13.	Nonalcoholic Fatty Liver Disease: An Emerging Driver of Hypertension
	Zhao YC^1,2, Zhao GJ^1,2, Chen Z^1,2, She ZG^1,2,3,4, Cai J^1,5,2, Li H^1,2,3. Hypertension. 2020 Feb;75(2):275-284. doi: 10.1161/HYPERTENSIONAHA.119.13419. Epub 2019 Dec 23.

14.	Derivation and Internal Validation of a Clinical Prediction Tool to Predict Nonalcoholic FattyLiver Disease in Patients With Crohn
	McHenry S¹, Tirath A², Tsai R³, Sharma Y⁴, Flores AG¹, Davidson NO¹, Fowler KJ^3,5, Ciorba MA^1,4, Deepak P^1,6. Inflamm Bowel Dis. 2020 Jan 7. pii: izz324. doi: 10.1093/ibd/izz324. [Epub ahead of print]

15.	Noninvasive assessment of hepatic steatosis and fibrosis in patients with severe obesity
	Coccia F¹, Testa M¹, Guarisco G¹, Bonci E², Di Cristofano C³, Silecchia G⁴, Leonetti F⁵, Gastaldelli A⁶, Capoccia D¹. Endocrine. 2019 Dec 19. doi: 10.1007/s12020-019-02155-w. [Epub ahead of print]

16.

Randomized Placebo-Controlled Trial of Emricasan in Non-alcoholic Steatohepatitis (NASH) Cirrhosis with Severe Portal Hypertension

Garcia-Tsao G¹, Bosch J², Kayali Z³, Harrison SA⁴, Abdelmalek MF⁵, Lawitz E⁶, Satapathy SK⁷, Ghabril M⁸, Shiffman ML⁹, Younes ZH¹⁰, Thuluvath PJ¹¹, Berzigotti A¹², Albillos A¹³, Robinson JM¹⁴, Hagerty DT¹⁴, Chan JL¹⁴, Sanyal AJ¹⁵; IDN-6556-14 Investigators. J Hepatol. 2019 Dec 20. pii: S0168-8278(19)30724-X. doi: 10.1016/j.jhep.2019.12.010. [Epub ahead of print]

17.	Moderate Alcohol Intake in Non-Alcoholic Fatty Liver Disease: To Drink or Not to Drink?
	Petroni ML¹, Brodosi L¹, Marchignoli F¹, Musio A¹, Marchesini G¹. Nutrients. 2019 Dec 13;11(12). pii: E3048. doi: 10.3390/nu11123048.

18.	Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial
	Cai H¹, Qin YL¹, Shi ZY¹, Chen JH¹, Zeng MJ¹, Zhou W¹, Chen RQ¹, Chen ZY². BMC Gastroenterol. 2019 Dec 18;19(1):219. doi: 10.1186/s12876-019-1132-8.

19.	Relationship between non-alcoholic fatty liver disease during pregnancy and abnormal glucose metabolism during and after pregnancy
	Sattari M¹, Bril F², Egerman R^2,3, Kalavalapalli S⁴, Cusi K^4,5,6. J Investig Med. 2019 Dec 17. pii: jim-2019-001186. doi: 10.1136/jim-2019-001186. [Epub ahead of print]

20.	Bariatric Surgery in Cirrhotic Patients: Is It Safe?
	Younus H¹, Sharma A¹, Miquel R¹, Quaglia A¹, Kanchustambam SR¹, Carswell KA¹, Patel AG². Obes Surg. 2019 Dec 18. doi: 10.1007/s11695-019-04214-7. [Epub ahead of print]

21.	Nonalcoholic Fatty Liver Disease: A Challenge from Mechanisms to Therapy
	Tarantino G¹, Citro V², Capone D³. J Clin Med. 2019 Dec 19;9(1). pii: E15. doi: 10.3390/jcm9010015.

22.	Disease Severity Is Associated With Higher Healthcare Utilization in Nonalcoholic Steatohepatitis Medicare Patients
	Gordon S¹, Fraysse J², Li S³, Ozbay AB², Wong RJ⁴. Am J Gastroenterol. 2019 Dec 12. doi: 10.14309/ajg.0000000000000484. [Epub ahead of print]

23.	Insulin Resistance and Genetic Risk Predict Liver-Related Outcomes and Death in Nonalcoholic Fatty Liver Disease
	Danford CJ¹, Jiang ZG¹, Salomaa V², Färkkilä M³, Jula A², Männistö S², Lundqvist A², Valsta L², Perola M², Åberg F^4,5. Hepatol Commun. 2019 Oct 10;3(12):1704-1705. doi: 10.1002/hep4.1437. eCollection 2019 Dec.

24.	Influence of lifestyle factors and staple foods from the Mediterranean diet on non-alcoholic fatty liver disease among older individuals with metabolic syndrome features
	Bullón-Vela V¹, Abete I², Tur JA³, Pintó X⁴, Corbella E⁴, Martínez-González MA⁵, Toledo E⁵, Corella D⁶, Macías M⁷, Tinahones F⁷, Fitó M⁸, Estruch R⁹, Ros E¹⁰, Salas-Salvadó J¹¹, Daimiel L¹², Zulet MA¹³, Martínez JA²; PREDIMED Plus investigators. Nutrition. 2019 Oct 25;71:110620. doi: 10.1016/j.nut.2019.110620. [Epub ahead of print]

25.	Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity
	Peña-Vélez R^1,2, Garibay-Nieto N^1,2,3, Cal-Y-Mayor-Villalobos M⁴, Laresgoiti-Servitje E⁵, Pedraza-Escudero K^1,2, García-Blanco MDC⁴, Heredia-Nieto OA⁶, Villanueva-Ortega E^1,2. J Pediatr Endocrinol Metab. 2019 Dec 16. pii: /j/jpem.ahead-of-print/jpem-2019-0204/jpem-2019-0204.xml. doi: 10.1515/jpem-2019-0204. [Epub ahead of print]

26.	A Review Of Current And Upcoming Treatment Modalities In Non-Alcoholic Fatty Liver DiseaseAnd Non-Alcoholic Steatohepatitis
	Ganguli S¹, DeLeeuw P², Satapathy SK³. Hepat Med. 2019 Nov 15;11:159-178. doi: 10.2147/HMER.S188991. eCollection 2019.

27.	Mediterranean Diet and NAFLD: What We Know and Questions That Still Need to Be Answered
	Plaz Torres MC^1,2,3, Aghemo A^3,4, Lleo A^3,4, Bodini G^1,2,3, Furnari M¹, Marabotto E¹, Miele L⁵, Giannini EG^1,2,6. Nutrients. 2019 Dec 5;11(12). pii: E2971. doi: 10.3390/nu11122971.

28.	Higher Sodium Intake Assessed by 24 Hour Urinary Sodium Excretion Is Associated with Non-Alcoholic Fatty Liver Disease: The PREVEND Cohort Study
	van den Berg EH^1,2, Gruppen EG^1,3, Blokzijl H², Bakker SJL³, Dullaart RPF¹. J Clin Med. 2019 Dec 6;8(12). pii: E2157. doi: 10.3390/jcm8122157.

29.	High Protein Diet and Metabolic Plasticity in Non-Alcoholic Fatty Liver Disease: Myths and Truths
	De Chiara F¹, Ureta Checcllo C², Ramón Azcón J¹. Nutrients. 2019 Dec 6;11(12). pii: E2985. doi: 10.3390/nu11122985.

30.	A retrospective case control study identifies peripheral blood mononuclear cell albumin RNA expression as a biomarker for non-alcoholic fatty liver disease
	Chu X¹, Karasinski K², Donellan S², Kaniper S², Wood GC¹, Shi W¹, Edwards MA³, Soans R³, Still CD¹, Gerhard GS⁴. Langenbecks Arch Surg. 2019 Dec 11. doi: 10.1007/s00423-019-01848-0. [Epub ahead of print]

31.	Impact of obeticholic acid on the lipoprotein profile in patients with non-alcoholic steatohepatitis
	Siddiqui MS1, Van Natta ML2, Connelly MA3, Vuppalanchi R4, Neuschwander-Tetri BA5, Tonascia J2, Guy C6, Loomba R7, Dasarathy S8, Wattacheril J9, Chalasani N4, Sanyal AJ10; NASH CRN. J Hepatol. 2019 Oct 18. pii: S0168-8278(19)30607-5. doi: 10.1016/j.jhep.2019.10.006. [Epub ahead of print]

32.	Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development
	Mouries J¹, Brescia P¹, Silvestri A¹, Spadoni I², Sorribas M³, Wiest R⁴, Mileti E⁵, Galbiati M⁶, Invernizzi P⁶, Adorini L⁷, Penna G⁸, Rescigno M⁹. J Hepatol. 2019 Dec;71(6):1216-1228. doi: 10.1016/j.jhep.2019.08.005. Epub 2019 Aug 13.

33.	REGENERATE: Design of a pivotal, randomised, phase 3 study evaluating the safety and efficacy of obeticholic acid in patients with fibrosis due to nonalcoholic steatohepatitis
	Ratziu V¹, Sanyal AJ², Loomba R³, Rinella M⁴, Harrison S⁵, Anstee QM⁶, Goodman Z⁷, Bedossa P⁸, MacConell L⁹, Shringarpure R⁹, Shah A⁹, Younossi Z⁷. Contemp Clin Trials. 2019 Sep;84:105803. doi: 10.1016/j.cct.2019.06.017. Epub 2019 Jun 29.

34.	Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis
	Loomba R¹, Sanyal AJ², Kowdley KV³, Terrault N⁴, Chalasani NP⁵, Abdelmalek MF⁶, McCullough AJ⁷, Shringarpure R⁸, Ferguson B⁸, Lee L⁸, Chen J⁸, Liberman A⁸, Shapiro D⁸, Neuschwander-Tetri BA⁹. Gastroenterology. 2019 Jan;156(1):88-95.e5. doi: 10.1053/j.gastro.2018.09.021. Epub 2018 Sep 15.

35.

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Younossi ZM¹, Ratziu V², Loomba R³, Rinella M⁴, Anstee QM⁵, Goodman Z¹, Bedossa P⁶, Geier A⁷, Beckebaum S⁸, Newsome PN⁹, Sheridan D¹⁰, Sheikh MY¹¹, Trotter J¹², Knapple W¹³, Lawitz E¹⁴, Abdelmalek MF¹⁵, Kowdley KV¹⁶, Montano-Loza AJ¹⁷, Boursier J¹⁸, Mathurin P¹⁹, Bugianesi E²⁰, Mazzella G²¹, Olveira A²², Cortez-Pinto H²³, Graupera I²⁴, Orr D²⁵, Gluud LL²⁶, Dufour JF²⁷, Shapiro D²⁸, Campagna J²⁸, Zaru L²⁸, MacConell L²⁸, Shringarpure R²⁸, Harrison S²⁹, Sanyal AJ³⁰; REGENERATE Study Investigators.

Collaborators (336) Lancet. 2019 Dec 5. pii: S0140-6736(19)33041-7. doi: 10.1016/S0140-6736(19)33041-7. [Epub ahead of print]

36.	Performance of liver biomarkers, in patients at risk of nonalcoholic steato-hepatitis, according to presence of type-2 diabetes
	Poynard T^1,2, Peta V^2,3, Deckmyn O³, Pais R^1,2, Ngo Y^2,3, Charlotte F⁴, Ngo A³, Munteanu M^2,3, Imbert-Bismut F⁵, Monneret D⁵, Housset C², Thabut D^1,2, Valla D⁶, Boitard C⁷, Castera L⁶, Ratziu V¹; FLIP consortium, the FibroFrance Group, the EPIC-3 program and the QUID-NASH group.

37.	The Role of Noninvasive Tests for Differentiating NASH From NAFL and Diagnosing Advanced Fibrosis Among Patients With NAFLD
	Balakrishnan M¹, Loomba R^2,3. J Clin Gastroenterol. 2019 Nov 26. doi: 10.1097/MCG.0000000000001284. [Epub ahead of print]

38.	Impact of NAFLD on the Incidence of Cardiovascular Diseases in a Primary Care Population in Germany
	Labenz C^1,2, Huber Y^1,2, Michel M^1,2, Nagel M^1,2, Galle PR^1,2, Kostev K³, Schattenberg JM^4,5. Dig Dis Sci. 2019 Dec 3. doi: 10.1007/s10620-019-05986-9. [Epub ahead of print]

39.	New drugs for NAFLD: lessons from basic models to the clinic
	Reimer KC¹, Wree A², Roderburg C², Tacke F³. Hepatol Int. 2019 Dec 4. doi: 10.1007/s12072-019-10001-4. [Epub ahead of print]

40.	Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease
	Smith GI, Shankaran M, Yoshino M, Schweitzer GG, Chondronikola M, Beals JW, Okunade AL, Patterson BW, Nyangau E, Field T, Sirlin CB, Talukdar S, Hellerstein MK, Klein S. J Clin Invest. 2019 Dec 5. pii: 134165. doi: 10.1172/JCI134165. [Epub ahead of print]

41.	A randomized, double-blind, multicenter, phase 2b study to evaluate the safety and efficacy of a combination of tropifexor and cenicriviroc in patients with nonalcoholic steatohepatitis and liver fibrosis: Study design of the TANDEM trial.
	Pedrosa M¹, Seyedkazemi S², Francque S³, Sanyal A⁴, Rinella M⁵, Charlton M⁶, Loomba R⁷, Ratziu V⁸, Kochuparampil J¹, Fischer L², Vaidyanathan S⁹, Anstee QM¹⁰. Contemp Clin Trials. 2019 Nov 13;88:105889. doi: 10.1016/j.cct.2019.105889. [Epub ahead of print]

42.	Liver stiffness measurement predicts long-term survival and complications in non-alcoholic fatty liver disease
	Shili-Masmoudi S¹, Wong GL^2,3, Hiriart JB¹, Liu K^4,5, Chermak F¹, Shu SS^2,3, Foucher J¹, Tse YK^2,3, Bernard PH¹, Yip TC^2,3, Merrouche W¹, Chan HL^2,3, Wong VW^2,3, de Lédinghen V^1,6. Liver Int. 2019 Nov 20. doi: 10.1111/liv.14301. [Epub ahead of print]

43.	The influence of Glucose-dependent Insulinotropic Polypeptide (GIP) on human adipose tissue and fat metabolism: implications for obesity, type 2 diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD)
	Thondam SK¹, Cuthbertson DJ², Wilding JPH³. Peptides. 2019 Nov 20:170208. doi: 10.1016/j.peptides.2019.170208. [Epub ahead of print]

44.	Moderate alcohol use in fatty liver disease; don
	Gow P^1,2, Testro AG^1,2, Hey P^1,2, Sinclair M^1,2. Hepatology. 2019 Nov 29. doi: 10.1002/hep.31049. [Epub ahead of print]

45.	Diabetes drugs for nonalcoholic fatty liver disease: a systematic review
	Blazina I¹, Selph S². Syst Rev. 2019 Nov 29;8(1):295. doi: 10.1186/s13643-019-1200-8.

46.	Systematic review and meta-analysis of Roux-en-Y gastric bypass against laparoscopic sleeve gastrectomy for amelioration of NAFLD using four criteria
	Baldwin D¹, Chennakesavalu M¹, Gangemi A². Surg Obes Relat Dis. 2019 Sep 18. pii: S1550-7289(19)30997-9. doi: 10.1016/j.soard.2019.09.060. [Epub ahead of print]

47.	Attributable Fractions of NAFLD for Mortality in the United States: Results From NHANES III With 27 Years of Follow-up
	Alvarez CS¹, Graubard BI¹, Thistle JE¹, Petrick JL^1,2, McGlynn KA¹. Hepatology. 2019 Nov 16. doi: 10.1002/hep.31040. [Epub ahead of print]

48.	Alcohol Use is Associated with Hepatic Steatosis Among Persons with Presumed Non-alcoholic Fatty Liver Disease
	Long MT¹, Massaro JM², Hoffmann U³, Benjamin EJ⁴, Naimi TS⁵. Clin Gastroenterol Hepatol. 2019 Nov 14. pii: S1542-3565(19)31309-6. doi: 10.1016/j.cgh.2019.11.022. [Epub ahead of print]

49.	Hypothetical Treatment of Patients with Nonalcoholic Steatohepatitis: Potential Impact on Important Clinical Outcomes
	Younossi ZM^1,2, Tampi RP¹, Nader F³, Younossi IM³, Cable R², Srishord M², Racila A^1,3. Liver Int. 2019 Nov 9. doi: 10.1111/liv.14292. [Epub ahead of print]

50.	Hypothetical Treatment of Patients with Nonalcoholic Steatohepatitis: Potential Impact on Important Clinical Outcomes
	Younossi ZM^1,2, Tampi RP¹, Nader F³, Younossi IM³, Cable R², Srishord M², Racila A^1,3. Liver Int. 2019 Nov 9. doi: 10.1111/liv.14292. [Epub ahead of print]

51.

GALAD Score Detects Early Hepatocellular Carcinoma in an International Cohort of Patients With Nonalcoholic Steatohepatitis

Best J¹, Bechmann LP¹, Sowa JP¹, Sydor S¹, Dechêne A², Pflanz K³, Bedreli S³, Schotten C³, Geier A⁴, Berg T⁵, Fischer J⁵, Vogel A⁶, Bantel H⁶, Weinmann A⁷, Schattenberg JM⁷, Huber Y⁷, Wege H⁸, von Felden J⁸, Schulze K⁸, Bettinger D⁹, Thimme R¹⁰, Sinner F¹, Schütte K¹, Weiss KH¹¹, Toyoda H¹², Yasuda S¹², Kumada T¹³, Berhane S¹⁴, Wichert M¹⁵, Heider D¹⁶, Gerken G³, Johnson P¹⁴, Canbay A¹⁷. Clin Gastroenterol Hepatol. 2019 Nov 8. pii: S1542-3565(19)31267-4. doi: 10.1016/j.cgh.2019.11.012. [Epub ahead of print]

52.	Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
	Harrison SA¹, Bashir MR², Guy CD², Zhou R³, Moylan CA², Frias JP⁴, Alkhouri N⁵, Bansal MB⁶, Baum S⁷, Neuschwander-Tetri BA⁸, Taub R⁹, Moussa SE¹⁰. Lancet. 2019 Nov 11. pii: S0140-6736(19)32517-6. doi: 10.1016/S0140-6736(19)32517-6. [Epub ahead of print]

53.	Pharmacological Therapy of Non-Alcoholic Fatty Liver Disease: What Drugs Are Available Now and Future Perspectives
	Pennisi G¹, Celsa C¹, Spatola F¹, Dallio M², Federico A², Petta S¹. Int J Environ Res Public Health. 2019 Nov 7;16(22). pii: E4334. doi: 10.3390/ijerph16224334.

54.	Niacin for treatment of nonalcoholic fatty liver disease (NAFLD): novel use for an old drug?
	Kashyap ML¹, Ganji S², Nakra NK², Kamanna VS³. J Clin Lipidol. 2019 Oct 14. pii: S1933-2874(19)30290-9. doi: 10.1016/j.jacl.2019.10.006. [Epub ahead of print]

55.	The Burden of Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: Screening Issue and Future Perspectives
	Pennisi G¹, Celsa C¹, Giammanco A², Spatola F¹, Petta S¹. Int J Mol Sci. 2019 Nov 9;20(22). pii: E5613. doi: 10.3390/ijms20225613.

56.	Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study
	Harrison SA¹, Alkhouri N², Davison BA³, Sanyal A⁴, Edwards C³, Colca JR⁵, Lee BH⁵, Loomba R⁶, Cusi K⁷, Kolterman O⁸, Cotter G³, Dittrich HC⁵. J Hepatol. 2019 Nov 4. pii: S0168-8278(19)30650-6. doi: 10.1016/j.jhep.2019.10.023. [Epub ahead of print]

57.	Transarterial Chemoembolization of Hepatocellular Carcinoma: Propensity Score Matching Study Comparing Survival and Complications in Patients with Nonalcoholic Steatohepatitis Versus Other Causes Cirrhosis
	Young S¹, Sanghvi T², Rubin N³, Hall D³, Roller L³, Charaf Y³, Golzarian J³. Cardiovasc Intervent Radiol. 2019 Nov 4. doi: 10.1007/s00270-019-02363-x. [Epub ahead of print]

58.	Effect of Metabolic Traits on the Risk of Cirrhosis and Hepatocellular Cancer in Non-alcoholic Fatty Liver Disease
	Kanwal F^1,2,3, Kramer J^2,3, Li L⁴, Dai J⁴, Natarajan Y¹, Yu X^2,3, Asch SM^5,6, El-Serag HB^1,2,3. Hepatology. 2019 Nov 1. doi: 10.1002/hep.31014. [Epub ahead of print]

59.	A multidisciplinary approach to the management of NAFLD is associated with improvement in markers of liver and cardio-metabolic health
	Moolla A^1,2, Motohashi K¹, Marjot T^1,3, Shard A³, Ainsworth M³, Gray A⁴, Holman R^2,5, Pavlides M^2,3, Ryan JD^2,3, Tomlinson JW^1,2, Cobbold JF^2,3. Frontline Gastroenterol. 2019 Oct;10(4):337-346. doi: 10.1136/flgastro-2018-101155. Epub 2019 Apr 30.

60.	Mortality Related to Nonalcoholic Fatty Liver Disease Is Increasing in the United States
	Paik JM¹, Henry L², De Avila L¹, Younossi E¹, Racila A¹, Younossi ZM^1,3. Hepatol Commun. 2019 Aug 14;3(11):1459-1471. doi: 10.1002/hep4.1419. eCollection 2019 Nov.

61.	Cardiovascular Risk Categories in Patients With Nonalcoholic Fatty Liver Disease and the Role of Low-Density Lipoprotein Cholesterol
	Labenz C¹, Prochaska JH^2,3,4, Huber Y¹, Nagel M¹, Straub BK⁵, Wild P^2,3,4, Galle PR¹, Schattenberg JM^1,6. Hepatol Commun. 2019 Sep 30;3(11):1472-1481. doi: 10.1002/hep4.1428. eCollection 2019 Nov.

62.	Hepatocellular carcinoma and non-alcoholic fatty liver disease
	Golabi P^1,2, Rhea L¹, Henry L², Younossi ZM^3,4. Hepatol Int. 2019 Nov 7. doi: 10.1007/s12072-019-09995-8. [Epub ahead of print]

63.	Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial
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358.	Randomised clinical trial: emricasan versus placebo significantly decreases ALT and caspase 3/7 activation in subjects with non-alcoholic fatty liver disease
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372.	Validation of Serum Test for Advanced Liver Fibrosis in Patients with Nonalcoholic Steatohepatitis
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379.	A Novel Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of NAFLD and HCC
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386.	Chronic Kidney Disease is Independently Associated with Increased Mortality in Patients with Non-alcoholic Fatty Liver Disease
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388.	Micronutrients in Nonalcoholic Fatty Liver Disease Pathogenesis
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389.	The global prevalence and genetic spectrum of lysosomal acid lipase deficiency: a rare condition that mimics NAFLD
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396.	Predictors of Nonalcoholic Steatohepatitis and Significant Fibrosis in Non-Obese Nonalcoholic Fatty Liver Disease
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398.	Hepatic Nuclear Receptor Expression Associates with Features of Histology in Pediatric Nonalcoholic Fatty Liver Disease
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399.	Among Patients With NAFLD, Treatment of Dyslipidemia Does Not Reduce Cardiovascular Mortality
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407.	Nonalcoholic Liver Disease in Children and Adolescents
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408.	Factors Associated with Histologic Response in Adult Patients with Nonalcoholic Steatohepatitis
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410.	Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease
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411.	Overview of Updated Practice Guidelines for Pediatric Nonalcoholic Fatty Liver Disease
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412.	C-peptide as a key risk factor for non-alcoholic fatty liver disease in the United States population
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413.	Utility and variability of three non-invasive liver fibrosis imaging modalities to evaluate efficacy of GR-MD-02 in subjects with NASH and bridging fibrosis during a phase-2 randomized clinical trial
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414.	Burden of Illness and Economic Model for Patients with Non-Alcoholic Steatohepatitis (NASH) in the United States
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416.	Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis
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417.	Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease
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420.	Unmet needs in pediatric NAFLD research: what do we need to prioritize for the future?
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425.	Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis
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426.	The Conundrum of Cryptogenic Cirrhosis: Adverse Outcomes without Treatment Options
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455.	The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the 13C-ketoisocaproate breath test
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469.	Type and Pattern of Alcohol Consumption is Associated With Liver Fibrosis in Patients With Non-alcoholic Fatty Liver Disease
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477.	Physical deconditioning is the common denominator in both obese and overweight subjects with nonalcoholic steatohepatitis
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486.	Mechanistic Potential and Therapeutic Implications of Cannabinoids in Nonalcoholic Fatty Liver Disease
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536.	Cardiometabolic Effects of Anti-obesity Pharmacotherapy
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537.	Unanticipated Increases in Hepatic Steatosis among HIV Patients Receiving MR Antagonist Eplerenone for NAFLD
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556.	Nonalcoholic fatty liver disease and the ongoing role of liver biopsy evaluation
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562.	Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005-2014
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563.	Improvement of Hepatic Fibrosis and Patient-Reported Outcomes in Non-Alcoholic Steatohepatitis Treated with Selonsertib
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569.	Vitamin E as a Treatment for Nonalcoholic Fatty Liver Disease: Reality or Myth?
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570.	Silymarin: An option to treat non-alcoholic fatty liver disease
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571.	Predictors of Non-Alcoholic Liver Disease in Ethnically Diverse Overweight Children and Adolescents
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572.	Origins of Portal Hypertension in Nonalcoholic Fatty Liver Disease
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575.	Pediatric Nonalcoholic Fatty Liver Disease: Current Thinking
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576.	Non-invasive, quantitative assessment of liver fat by MRI-PDFF as an endpoint in NASH trials
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577.	New scoring system combining the FIB-4 index and cytokeratin-18 fragments for predicting steatohepatitis and liver fibrosis in patients with nonalcoholic fattyliver disease
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580.	Obese children with fatty liver: Between reality and disease mongering
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581.	Low Circulating Levels of Neurotensin in Women with Nonalcoholic Fatty LiverDisease Associated with Severe Obesity
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582.	Clinical epidemiology and disease burden of nonalcoholic fatty liver disease
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583.	An updated meta-analysis of pioglitazone exposure and bladder cancer and comparison to the drug's effect on cardiovascular disease and non-alcoholic steatohepatitis
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585.	Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis
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586.	Liver transplantation for NASH-related hepatocellular carcinoma versus non-NASH etiologies of hepatocellular carcinoma
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587.	Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis
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588.	Epidemic of non-alcoholic fatty liver disease and hepatocellular carcinoma
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589.	Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus
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590.	Prevention of Tamoxifen-related Nonalcoholic Fatty Liver Disease in Breast Cancer Patients
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592.	Current and future pharmacological therapies for NAFLD/NASH
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593.	Fatty acids in non-alcoholic steatohepatitis: Focus on pentadecanoic acid
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594.	Clinical course of nonalcoholic fatty liver disease: an assessment of severity, progression, and outcomes
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595.	Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease
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596.	Relationship between Hypothyroidism and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
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597.	Association between nonalcoholic fatty liver disease and subclinical coronary atherosclerosis: An observational cohort study
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598.	Non-Alcoholic Fatty Liver Disease and HIV/AIDS: A New Way of Modulation of Cardiovascular Risk
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599.	Clinical relevance of liver histopathology and different histological classifications of NASH in adults
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601.	Liver Transplantation in Cryptogenic Cirrhosis: Outcome comparisons between NASH, Alcoholic and AIH cirrhosis
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602.	Non-alcoholic Fatty Liver Disease: A Clinical Update
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603.	Too much medicine: overdiagnosis and overtreatment of non-alcoholic fatty liver disease
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604.	Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279?013 individuals
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605.	Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial
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606.	Alcohol Consumption in Diabetic Patients with Nonalcoholic Fatty Liver Disease
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607.	Response to Pioglitazone in Patients With Nonalcoholic Steatohepatitis With vs Without Type 2 Diabetes
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610.	Fibromax-based nonalcoholic fatty liver disease in chronic obstructive pulmonary disease patients with obstructive sleep apnea: Methodological considerations
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612.	Liver zonation in children with NAFLD: associations with dietary fructose and uric acid concentrations
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614.	Non-alcoholic fatty liver disease and lifestyle modifications, focusing on physical activity
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615.	Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-Aged Adults in the Framingham Study
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616.	Cardiovascular Disease, Cancer, and Mortality Among People With Type 2 Diabetes and Alcoholic or Nonalcoholic Fatty Liver Disease Hospital Admission
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617.	Role of imaging based biomarkers in NAFLD: Recent advances in clinical application and future research directions
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618.	Investigating Molecular Connections of Non-alcoholic Fatty Liver Disease with Associated Pathological Conditions in West Virginia for Biomarker Analysis
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619.	Diagnosis and Evaluation of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Including Noninvasive Biomarkers and Transient Elastography
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620.	Clinical and Histologic Characterization of Nonalcoholic Steatohepatitis in African American Patients
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621.	Text messaging approach improves weight loss in patients with nonalcoholic fatty liver disease: A randomized study
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622.	Pathophysiology of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
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623.	Risk Factors for the Development of Nonalcoholic Fatty LiverDisease/Nonalcoholic Steatohepatitis, Including Genetics
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624.	Clinical and Economic Burden of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
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625.	Bariatric Surgery as an Efficient Treatment for Non-Alcoholic Fatty Liver Diseasein a Prospective Study with 1-Year Follow-up : BariScan Study
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626.	Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis in Liver Transplantation
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627.	Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?
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628.	Risk factors for biopsy-proven advanced non-alcoholic fatty liver disease in the Veterans Health Administration
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630.	Non-alcoholic Fatty Liver Disease in Morbidly Obese Individuals Undergoing Bariatric Surgery: Prevalence and Effect of the Pre-Bariatric Very Low Calorie Diet
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631.	Nonalcoholic Fatty Liver Disease and Metabolic Syndrome
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632.	Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma
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633.	Pharmacotherapy for NASH: Current and emerging
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634.	Review article: the gut microbiome as a therapeutic target in the pathogenesis and treatment of chronic liver disease
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635.	Endocrine Disruptors and Developmental Origins of Nonalcoholic Fatty Liver Disease
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636.	Care standards for non-alcoholic fatty liver disease in the United Kingdom 2016: a cross-sectional survey
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637.	The Natural History of Nonalcoholic Fatty Liver Disease-An Evolving View
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638.	The Use of Liver Biopsy in Nonalcoholic Fatty Liver Disease: When to Biopsy and in Whom
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639.	Steatosis and NASH in type 2 diabetes
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640.	Nonalcoholic Steatohepatitis (NASH) and Hepatic Fibrosis: Emerging Therapies
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641.	The Microbiome That Shapes Us: Can It Cause Obesity?
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642.	Adherence to Mediterranean Diet and Non-Alcoholic Fatty Liver Disease: Effect on Insulin Resistance
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643.	Updates on Dietary Models of Non-Alcoholic Fatty Liver Disease: Current Studies and Insights
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644.	Non-invasive diagnosis of non-alcoholic fatty liver disease (NAFLD) using ultrasound image echogenicity
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645.	Impact of bariatric surgery on outcomes of patients with nonalcoholic fatty liverdisease: a nationwide inpatient sample analysis, 2004-2012
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646.	Benefit-risk of intraoperative liver biopsy during bariatric surgery: review and perspectives
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647.	Treatment Strategies for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
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656.	Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals
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657.	Rising Rates of Hepatocellular Carcinoma Leading to Liver Transplantation in Baby Boomer Generation with Chronic Hepatitis C, Alcohol Liver Disease, and Nonalcoholic Steatohepatitis-Related Liver Disease
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680.	Host factors are dominant in the development of post-liver transplant non-alcoholic steatohepatitis
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684.	Gut Microbiota and Lifestyle Interventions in NAFLD
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685.	A Comprehensive Updated Review of Pharmaceutical and Nonpharmaceutical Treatment for NAFLD
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695.	Histamine H2-Receptor Antagonist Use Is Associated With Lower Prevalence of Nonalcoholic Fatty Liver Disease: A Population-based Study From the National Health and Nutrition Examination Survey, 2001-2006
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705.	The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis
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715.	The Gut Microbiota and Nonalcoholic Fatty Liver Disease
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716.	Systemic Complications of Nonalcoholic Fatty Liver Disease: When the Liver Is Not an Innocent Bystander
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717.	Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability
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718.	Relevance of low testosterone to non-alcoholic fatty liver disease
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722.	The Prevalence and Presumed Etiology of Elevated Aminotransferase Levels in a Pacific Northwest Tribal Community
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723.	Burden of nonalcoholic fatty liver disease and advanced fibrosis in a Texas Hispanic community cohort
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724.	Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease
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725.	Cost-Effective Evaluation of Nonalcoholic Fatty Liver Disease With NAFLD Fibrosis Score and Vibration Controlled Transient Elastography
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726.	Nonmedicinal interventions in nonalcoholic fatty liver disease
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727.	Non-alcoholic fatty liver disease following liver transplantation: a clinical review
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728.	Vitamin E has a beneficial effect on nonalcoholic fatty liver disease: a meta-analysis of randomized controlled trials
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729.	Noninvasive Assessment of Fibrosis in Patients with Nonalcoholic Fatty Liver Disease
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730.	Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?
	Kohli R1, Myronovych A, Tan BK, Salazar-Gonzalez RM, Miles L, Zhang W, Oehrle M, Sandoval DA, Ryan KK, Seeley RJ, Setchell KD. Dig Dis. 2015;33(3):440-6. doi: 10.1159/000371699. Epub 2015 May 27.

731.	Trends in the Burden of Non-alcoholic Fatty Liver Disease in a US Cohort of Veterans
	Kanwal F1, Kramer JR2, Duan Z2, Yu X3, White D4, El-Serag HB5. Clin Gastroenterol Hepatol. 2015 Aug 17. pii: S1542-3565(15)01109-X. doi: 10.1016/j.cgh.2015.08.010. [Epub ahead of print]

732.	Hepatocellular Carcinoma in the Setting of Non-cirrhotic Nonalcoholic Fatty Liver Disease and the Metabolic Syndrome: US Experience.
	Perumpail RB1, Wong RJ, Ahmed A, Harrison SA. Dig Dis Sci. 2015 Aug 7. [Epub ahead of print]

733.	Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis.
	Vilar-Gomez E1, Martinez-Perez Y2, Calzadilla-Bertot L2, Torres-Gonzalez A2, Gra-Oramas B3, Gonzalez-Fabian L3, Friedman SL4, Diago M5, Romero-Gomez M6. Gastroenterology. 2015 Aug;149(2):367-378.e5. doi: 10.1053/j.gastro.2015.04.005. Epub 2015 Apr 10.

734.	Association of Non-alcoholic Fatty Liver Disease (NAFLD) with Hepatocellular Carcinoma (HCC) in the United States from 2004-2009
	Younossi ZM1,2,3, Otgonsuren M3, Henry L1,3, Venkatesan C2, Mishra A1, Erario M2, Hunt S1. Hepatology. 2015 Aug 14. doi: 10.1002/hep.28123. [Epub ahead of print]

735.	NAFLD Review: Diagnosis, Treatment and Outcomes
	Ahmed A1, Wong RJ2, Harrison SA3. Clin Gastroenterol Hepatol. 2015 Jul 27. pii: S1542-3565(15)00988-X. doi: 10.1016/j.cgh.2015.07.029. [Epub ahead of print]

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