Topics will include emerging data, a discussion regarding outcomes associated with earlier diagnosis and treatment, acute-on-chronic liver failure grading as a clinical decision tool, current and emerging treatments, and current guidelines/recommendations.

Learning Objectives:

Upon completion of this activity, participants should be able to:

  • Discuss criteria for the diagnosis and management of AKI in cirrhosis
  • Recognize the differing treatment goals in HRS (i.e., long-term treatment improvement of liver function vs. short-term improvement of kidney function)
  • Recognize the need for approved therapies for HRS in the US and apply recommended treatment strategies to clinical practice in the absence of these therapies
  • Identify new advancements in the treatment of HRS

Supported by an educational grant from Mallinckrodt Pharmaceuticals.


Welcome and Introduction

Hepatorenal Syndrome (HRS):
Review of Updated Guidelines and Treatment Options

Case 1: Diagnosis and Management Considerations of HRS-AKI

Case 2: Considerations of Management of HRS-AKI in the ICU Setting

Panel Discussion and Q&A

Robert S. Brown, Jr., MD., MPH - Chair

Vincent Astor Distinguished Professor of Medicine
Chief, Division of Gastroenterology & Hepatology
Editor-in-Chief, Liver Transplantation
Weill Cornell Medicine
New York, NY


Dr. Brown is the Vincent Astor Distinguished Professor of Medicine and Chief of the Division of Gastroenterology and Hepatology at Weill Cornell Medical College in New York City.

He received his AB from Harvard College, his MD from New York University and a MPH from the University of California, Berkeley. He did his residency at Beth Israel Hospital/Harvard Medical School, and a fellowship in gastroenterology and hepatology at UCSF.

He has co-authored over 200 peer-reviewed articles and is the Editor-In-Chief for Liver Transplantation. Dr. Brown received the Young Investigator Award from the American Society of Transplant Physicians, the Senior Attending Teaching Award at Columbia University College of Physicians & Surgeons and the American Liver Foundation New York chapter Physician of the Year.

Faculty Disclosures

Grants/Research Support: Mallinckrodt

Consulting Fees: Mallinckrodt

Kimberly A. Brown, MD

Chief, Division of Gastroenterology and Hepatology
Henry Ford Health System
Detroit, MI

Faculty Disclosures

Grants/Research Support:Sagiment, Novonordisk, Salix

Consulting Fees: Gilead, Salix, Intercept

Speakers Bureau: Gilead, Intercept, Salix

Steven Flamm, MD

Chief of Hepatology
Medical Director of Liver Transplantation
Professor of Medicine and Surgery
Northwestern Feinberg School of Medicine
Chicago, IL

Faculty Disclosures

Consulting Fees: Mallinckrodt