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About CLDF
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HCC-Single Disease Content  
HCC Care Cascade Decision-Support Tool
 
Publications
 
Webcasts
     
New Advances in HCC Therapies   Educational Webcast
Slide Library
   Released: 2022
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New Advances in HCC Therapies
61 slides
 
 
   Released: 2021
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Management and Treatment of HCC is Optimized in a Multidisciplinary Liver Tumor Board
61 slides
 
 
   Released: 2021
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Sequence of Currently Approved Systemic Therapies for HCC: From First Line to Second Line and Beyond
53 slides
 
 
   Released: 2021
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The Role of Precision Medicine in the Management and Treatment of HCC
33 slides
 
 
   Released: 2021
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Integration of Immuno-Oncology to Improve HCC Outcomes: Immune Checkpoint Inhibition and Potential Synergies with Interventional Radiology and Radiation Oncology
30 slides
 
 
   Released: 2021
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Non-Cirrhotic Risk Factors for HCC in Patients with NAFLD
35 slides
 
 
   Released: 2021
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Recommendations to Optimize Surveillance of HCC
33 slides
 
 
   Released: 2021
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Epidemiology and Surveillance for Hepatocellular Carcinoma
31 slides
 
 
   Released: 2021
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Current Surgical Resection for Primary Liver Malignancies
87 slides
 
 
   Released: 2021
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Second Line Therapies in HCC
30 slides
 
 
   Released: 2021
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Thermal Ablation for HCC
96 slides
 
 
   Released: 2021
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Transarterial Therapies for HCC: TACE and Y90
38 slides
 
 
   Released: 2021
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Imaging of HCC Surveillance, Diagnosis, and Prognosis
38 slides
 
 
   Released: 2021
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Update on the Front-Line Management of Advanced HCC
33 slides
 
 
   Released: 2021
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Liver Transplantation for Patients with Hepatocellular Carcinoma
33 slides
 
 
   Released: 2021
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HCC Research Update: From Bedside to Bench-side and Back to Bedside
26 slides
 
 
   Released: 2020
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How to Approach HCV Treatment in Patients With HCC - DAA Before or After Liver Transplantation
40 slides
 
 
   Released: 2020
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Down-Staging of Hepatocellular Carcinoma Before Liver Transplantation: Tumor Burden, Alpha-Fetoprotein and Wait Time Predict of Tumor Biology
45 slides
 
 
   Released: 2020
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HCC Risk Biomarkers 2021: State of the Art and Future Perspective
65 slides
 
 
   Released: 2020
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Novel Treatments and Emerging Targets for Hepatocellular Carcinoma (HCC)
52 slides
 
 
   Released: 2020
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Surgical Options for Treatment of HCC - Resection vs. Liver Transplantation (LT)
74 slides
 
 
   Released: 2020
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Interventional Oncology: Hepatocellular Carcinoma
63 slides
 
 
   Released: 2020
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Update on HCC Clinical Trials: Barcelona HCC Criteria and Phase III Data
60 slides
 
 
   Released: 2020
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Disparities in Linkage to Care for HCC
35 slides
 
 
   Released: 2020
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HCC Surveillance in an Era of Biomarkers: Application of State-of-the-Art Tools
59 slides
 
 
   Released: 2020
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Overview of Treatment Approaches to Hepatocellular Carcinoma
47 slides
 
 
   Released: 2020
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Diagnosis and Staging of HCC
38 slides
 
 
   Released: 2020
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Global HCC Trends: Implications for Prevention
54 slides
 
 
   Released: 2020
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Changing Epidemiology of HCC in the U.S.
55 slides
 
 
   Released: 2020
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Populations at High Risk for HCC in the U.S. - Implications for Clinical Practice
59 slides
 
 
   Released: 2019
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Epidemiology HCC Innovations
21 slides
 
 
   Released: 2019
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Intra-Arterial Therapies
25 slides
 
 
   Released: 2019
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Immunotherapy for HCC and Emerging Treatments
72 slides
 
 
   Released: 2019
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Liver Transplant for Hepatocellular Carcinoma
22 slides
 
 
   Released: 2019
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Systemic Therapy for Liver Cancer
46 slides
 
 
   Released: 2019
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Imaging and Biomarkers in HCC: Diagnosis and Surveillance
29 slides
 
 
   Released: 2019
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Defining Outcomes of Hepatocellular Carcinoma therapy
51 slides
 
 
   Released: 2019
Webcast
Determining Hepatocellular Carcinoma Staging:Liver Disease Staging, Performance Status and RECIST Criteria
38 slides
 
 
   Released: 2019
Webcast
Surveillance for Hepatocellular Carcinoma
37 slides
 
 
   Released: 2018
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Hepatology News Tonight: Managing Complication of Cirrhosis
57 slides
 
   
 
 
Abstract Library
1.Donafenib in hepatocellular carcinoma
 

Drugs Today (Barc). 2023 Feb;59(2):83-90. doi: 10.1358/dot.2023.59.2.3507751.

Rusi Chen 1, Luca Ielasi 1, Alma di Carlo 2, Francesco Tovoli 3 2
 
2.The Performance of AFP, AFP-3, DCP as Biomarkers for Detection of Hepatocellular Carcinoma (HCC): A Phase 3 Biomarker Study in the United States
 

Clin Gastroenterol Hepatol. 2023 Feb;21(2):415-423.e4. doi: 10.1016/j.cgh.2022.01.047.Epub 2022 Feb 3.

Nabihah Tayob 1, Fasiha Kanwal 2, Abeer Alsarraj 2, Ruben Hernaez 2, Hashem B El-Serag 3
 
3.HCC EV ECG score: An extracellular vesicle-based protein assay for detection of early-stage hepatocellular carcinoma
 

Hepatology. 2023 Mar 1;77(3):774-788. doi: 10.1002/hep.32692. Epub 2023 Feb 17.

Na Sun 1 2, Ceng Zhang 1 3, Yi-Te Lee 1, Benjamin V Tran 4, Jing Wang 1, Hyoyong Kim 1, Junseok Lee 1, Ryan Y Zhang 1, Jasmine J Wang 1 5, Junhui Hu 6, Zhicheng Zhang 6, Manaf S Alsudaney 7, Kuan-Chu Hou 1, Hubert Tang 1, Tiffany X Zhang 1, Icy Y Liang 1, Ziang Zhou 1, Mengxiang Chen 1, Angela Hsiao-Jiun Yeh 8, Wenyuan Li 9, Xianghong Jasmine Zhou 9, Helena R Chang 4, Steven-Huy B Han 8, Saeed Sadeghi 8, Richard S Finn 8, Sammy Saab 8, Ronald W Busuttil 4, Mazen Noureddin 7 10, Walid S Ayoub 7 10, Alexander Kuo 7 10, Vinay Sundaram 7 10, Buraq Al-Ghaieb 7 10, Juvelyn Palomique 7, Kambiz Kosari 7, Irene K Kim 7, Tsuyoshi Todo 7, Nicholas N Nissen 7, Maria Lauda Tomasi 10, Sungyong You 11, Edwin M Posadas 5, James X Wu 4, Madhuri Wadehra 9, Myung-Shin Sim 12, Yunfeng Li 9, Hanlin L Wang 9, Samuel W French 9, Shelly C Lu 10 13, Lily Wu 6, Renjun Pei 2, Li Liang 14 15, Ju Dong Yang 7 10 13, Vatche G Agopian 4 16, Hsian-Rong Tseng 1 16, Yazhen Zhu 1 9 16
 
4.Imaging Diagnosis of Hepatocellular Carcinoma: A State-of-the-Art Review
 

Diagnostics (Basel). 2023 Feb 8;13(4):625. doi: 10.3390/diagnostics13040625.

Gianvito Candita 1, Sara Rossi 1, Karolina Cwiklinska 1, Salvatore Claudio Fanni 1, Dania Cioni 1, Riccardo Lencioni 1, Emanuele Neri 1
 
5.Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors
 

Nat Rev Gastroenterol Hepatol. 2023 Jan;20(1):37-49.doi: 10.1038/s41575-022-00688-6. Epub 2022 Oct 18.

Daniel Q Huang 1 2 3, Philippe Mathurin 4 5, Helena Cortez-Pinto 6, Rohit Loomba 7 8
 
6.Genetics of Hepatocellular Carcinoma: From Tumor to Circulating DNA
 

Cancers (Basel). 2023 Jan 28;15(3):817. doi: 10.3390/cancers15030817.

Claudia Campani 1 2 3, Jessica Zucman-Rossi 1 2 4, Jean-Charles Nault 1 2 5 6
 
7.Immunotherapy in hepatocellular carcinoma: how will it reshape treatment sequencing?
 

Ther Adv Med Oncol. 2023 Jan 10;15:17588359221148029.doi: 10.1177/17588359221148029. eCollection 2023.

Antonella Cammarota 1 2, Valentina Zanuso 1 3, Giulia Francesca Manfredi 4, Ravindhi Murphy 5, David James Pinato 5 6, Lorenza Rimassa 7 8
 
8.Salvage locoregional therapies for recurrent hepatocellular carcinoma
 

World J Gastroenterol. 2023 Jan 21;29(3):413-424. doi: 10.3748/wjg.v29.i3.413.

Cody R Criss 1, Mina S Makary 2
 
9.Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease: The Prognostic Role of Liver Stiffness Measurement
 

Cancers (Basel). 2023 Jan 19;15(3):637. doi: 10.3390/cancers15030637.

Lucia Cerrito 1, Irene Mignini 1, Maria Elena Ainora 1, Carolina Mosoni 1, Antonio Gasbarrini 1, Maria Assunta Zocco 1
 
10.Five years of lenvatinib in hepatocellular carcinoma: are there any predictive and/or prognostic factors?
 

Expert Rev Anticancer Ther. 2023 Jan;23(1):19-27.doi: 10.1080/14737140.2023.2156340. Epub 2022 Dec 14.

Mara Persano 1, Andrea Casadei-Gardini 2, Valentina Burgio 3, Mario Scartozzi 1, Stefano Cascinu 2, Margherita Rimini 3
 
11.Epidemiological trends and trajectories of MAFLD-associated hepatocellular carcinoma 2002-2033: the ITA.LI.CA database
 

Gut. 2023 Jan;72(1):141-152. doi: 10.1136/gutjnl-2021-324915. Epub 2021 Dec 21.

Alessandro Vitale # 1, Gianluca Svegliati-Baroni # 2 3, Alessio Ortolani 4, Monica Cucco 5 6, Giulio V Dalla Riva 7, Edoardo G Giannini 8, Fabio Piscaglia 9, Gianludovico Rapaccini 10, Mariella Di Marco 11, Eugenio Caturelli 12, Marco Zoli 13, Rodolfo Sacco 14, Giuseppe Cabibbo 15, Fabio Marra 16, Andrea Mega 17, Filomena Morisco 18, Antonio Gasbarrini 19, Francesco Giuseppe Foschi 20, Gabriele Missale 21, Alberto Masotto 22, Gerardo Nardone 23, Giovanni Raimondo 24, Francesco Azzaroli 25, Gianpaolo Vidili 26, Filippo Oliveri 27, Filippo Pelizzaro 1, Rafael Ramirez Morales 1, Umberto Cillo 1, Franco Trevisani 28, Luca Miele 29 30, Giulio Marchesini 31, Fabio Farinati 1; Italian Liver Cancer (ITA.LI.CA) group
 
12.Performance of Radiomics in Microvascular Invasion Risk Stratification and Prognostic Assessment in Hepatocellular Carcinoma: A Meta-Analysis
 

Cancers (Basel). 2023 Jan 25;15(3):743. doi: 10.3390/cancers15030743.

Sylvain Bodard 1 2 3, Yan Liu 4 5, Sylvain Guinebert 1 2, Yousra Kherabi 2, Tarik Asselah 2 6
 
13.Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease
 

J Hepatol. 2023 Jan;78(1):191-206. doi: 10.1016/j.jhep.2022.08.030.Epub 2022 Sep 5.

Fredrik Åberg 1, Christopher D Byrne 2, Carlos J Pirola 3, Ville Männistö 4, Silvia Sookoian 5
 
14.COVID-19: Has the Liver Been Spared?
 

Int J Mol Sci. 2023 Jan 6;24(2):1091. doi: 10.3390/ijms24021091.

Nicolò Brandi 1, Daniele Spinelli 1, Alessandro Granito 2, Francesco Tovoli 2, Fabio Piscaglia 2, Rita Golfieri 1, Matteo Renzulli 1
 
15.The Diagnostic Approach towards Combined Hepatocellular-Cholangiocarcinoma-State of the Art and Future Perspectives
 

Cancers (Basel). 2023 Jan 1;15(1):301. doi: 10.3390/cancers15010301.

Johannes Eschrich 1, Zuzanna Kobus 1, Dominik Geisel 2, Sebastian Halskov 2, Florian Roßner 3, Christoph Roderburg 4, Raphael Mohr 1, Frank Tacke 1
 
16.Tremelimumab: First Approval
 

Drugs. 2023 Jan;83(1):93-102. doi: 10.1007/s40265-022-01827-8.

Susan J Keam 1
 
17.Pathology of Combined Hepatocellular Carcinoma-Cholangiocarcinoma: An Update
 

Cancers (Basel). 2023 Jan 13;15(2):494. doi: 10.3390/cancers15020494.

Florian Roßner 1, Bruno Valentin Sinn 1, David Horst 1 2
 
18.Immune-Based Combinations versus Sorafenib as First-Line Treatment for Advanced Hepatocellular Carcinoma: A Meta-Analysis
 

Curr Oncol. 2023 Jan 5;30(1):749-757. doi: 10.3390/curroncol30010057.

Alessandro Rizzo 1, Angela Dalia Ricci 2, Annarita Fanizzi 3, Raffaella Massafra 3, Raffaele De Luca 4, Giovanni Brandi 5 6
 
19.FDA-Approved Monoclonal Antibodies for Unresectable Hepatocellular Carcinoma: What Do We Know So Far?
 

Int J Mol Sci. 2023 Jan 31;24(3):2685. doi: 10.3390/ijms24032685.

Iason Psilopatis 1, Christos Damaskos 2 3, Anna Garmpi 4, Panagiotis Sarantis 5, Evangelos Koustas 5, Efstathios A Antoniou 3 6, Dimitrios Dimitroulis 6, Gregory Kouraklis 6, Michail V Karamouzis 5, Kleio Vrettou 7, Georgios Marinos 8, Konstantinos Kontzoglou 3 6, Nikolaos Garmpis 3 6
 
20.Combined Loco-Regional and Systemic Treatment Strategies for Hepatocellular Carcinoma: From Basics to New Developments
 

Cardiovasc Intervent Radiol. 2022 Dec 7. doi: 10.1007/s00270-022-03327-4.Online ahead of print.

Angelo Della Corte 1 2 3, Margherita Rimini 4, Stephanie Steidler 5, Diego Palumbo 5 6 7, Francesca Ratti 8, Luca Aldrighetti 7 8, Stefano Cascinu 7 4, Andrea Casadei-Gardini 4, Francesco De Cobelli 5 6 7
 
21.An Open-Access, Interactive Decision-Support Tool to Facilitate Guideline-Driven Care for Hepatocellular Carcinoma
 

Gastroenterology Res. 2022 Dec;15(6):297-307. doi: 10.14740/gr1573.Epub 2022 Dec 1.

Robert J Wong 1, Channa Jayasekera 2, Patricia Jones 3, Fasiha Kanwal 4, Amit G Singal 5, Aijaz Ahmed 6, Robert Taglienti 7, Zobair Younossi 8, Laura Kulik 9, Neil Mehta 10
 
22.Prognostic Role of Neutrophil-to-Lymphocyte Ratio (NLR), Lymphocyte-to-Monocyte Ratio (LMR), Platelet-to-Lymphocyte Ratio (PLR) and Lymphocyte-to-C Reactive Protein Ratio (LCR) in Patients with Hepatocellular Carcinoma (HCC) undergoing Chemoembolizations (TACE) of the Liver: The Unexplored Corner Linking Tumor Microenvironment, Biomarkers and Interventional Radiology
 

Cancers (Basel). 2022 Dec 30;15(1):257. doi: 10.3390/cancers15010257.

Roberto Minici 1, Maria Anna Siciliano 2, Michele Ammendola 3, Rita Carlotta Santoro 4, Vito Barbieri 2, Girolamo Ranieri 5, Domenico Laganà 6
 
23.Expert Insights on Current Treatments for Hepatocellular Carcinoma: Clinical and Molecular Approaches and Bottlenecks to Progress
 

J Hepatocell Carcinoma. 2022 Dec 7;9:1247-1261. doi: 10.2147/JHC.S383922.eCollection 2022.

Alexander H Shannon 1, Samantha M Ruff 1, Timothy M Pawlik 1
 
24.Ramucirumab for Patients with Advanced Hepatocellular Carcinoma and Elevated Alpha Fetoprotein Following Non-Sorafenib Systemic Therapy: An Expansion Cohort of REACH-2
 

Oncologist. 2022 Dec 9;27(12):e938-e948. doi: 10.1093/oncolo/oyac183.

Richard S Finn 1, Thomas Yau 2, Chih-Hung Hsu 3, Enrico N De Toni 4, Lipika Goyal 5, Peter R Galle 6, ShuKui Qin 7, Sujata Rao 8, Fangfang Sun 8, Chunxiao Wang 8, Ryan C Widau 8, Andrew X Zhu 9 10
 
25.Improved survival and higher rates of surgical resection associated with hepatocellular carcinoma in children as compared to young adults
 

Int J Cancer. 2022 Dec 15;151(12):2206-2214. doi: 10.1002/ijc.34215. Epub 2022 Aug 11.

Sarah Jane Commander 1, Marcelo Cerullo 2, Neha Arjunji 3, Harold J Leraas 1, Steven Thornton 3, Kadiyala Ravindra 4, Elisabeth T Tracy 1
 
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