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Preliminary evidence for hdv exposure in apparently non-HBV-infected patients |
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Hepatology. 2020 Jul 6. doi: 10.1002/hep.31453. Online ahead of print.
Isabelle Chemin 1, Flor H Pujol 2, Caroline Scholtès 1 3, Carmen L Loureiro 2, Fouzia Amirache 4, Massimo Levrero 1 5, Fabien Zoulim 1 5, Jimena Pérez-Vargas 4, François-Loïc Cosset 4
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Author information
- 1Cancer Research Center of Lyon (CRCL), UMR Inserm 1052 - CNRS 5286 mixte CLB - UCBL1, F- 69008, Lyon, France.
- 2Laboratorio de Virología Molecular, CMBC, IVIC, Apdo 20632, Caracas, 1020A, Venezuela.
- 3Laboratoire de Virologie, Groupement Hospitalier Nord, Institut des Agents Infectieux, CBN, Hospices Civil de Lyon, F- 69004, Lyon, France.
- 4CIRI, Centre International de Recherche en Infectiologie, Team EVIR, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.
- 5Department of Hepatology, Hôpital de la Croix Rousse, Hospices Civil de Lyon, F- 69004, Lyon, France.
Abstract
Hepatitis delta virus (HDV) is a defective human virus that lacks the ability to produce its own envelope proteins and is thus dependent on the presence of a helper virus, which provides its surface proteins to produce infectious particles. Hepatitis B virus (HBV) was so far thought to be the only helper virus described to be associated to HDV. However, recent studies showed that divergent HDV-like viruses can be detected in fishes, birds, amphibians, and invertebrates, without evidence of any HBV-like agent supporting infection.
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