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Abstract Details
Preliminary evidence for hdv exposure in apparently non-HBV-infected patients
Hepatology. 2020 Jul 6. doi: 10.1002/hep.31453. Online ahead of print.
Isabelle Chemin1, Flor H Pujol2, Caroline Scholtès13, Carmen L Loureiro2, Fouzia Amirache4, Massimo Levrero15, Fabien Zoulim15, Jimena Pérez-Vargas4, François-Loïc Cosset4
Author information
1Cancer Research Center of Lyon (CRCL), UMR Inserm 1052 - CNRS 5286 mixte CLB - UCBL1, F- 69008, Lyon, France.
3Laboratoire de Virologie, Groupement Hospitalier Nord, Institut des Agents Infectieux, CBN, Hospices Civil de Lyon, F- 69004, Lyon, France.
4CIRI, Centre International de Recherche en Infectiologie, Team EVIR, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.
5Department of Hepatology, Hôpital de la Croix Rousse, Hospices Civil de Lyon, F- 69004, Lyon, France.
Abstract
Hepatitis delta virus (HDV) is a defective human virus that lacks the ability to produce its own envelope proteins and is thus dependent on the presence of a helper virus, which provides its surface proteins to produce infectious particles. Hepatitis B virus (HBV) was so far thought to be the only helper virus described to be associated to HDV. However, recent studies showed that divergent HDV-like viruses can be detected in fishes, birds, amphibians, and invertebrates, without evidence of any HBV-like agent supporting infection.
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