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Abstract Details |
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Presence of Serum Antinuclear Antibodies Does Not Impact Long-Term Outcomes in Nonalcoholic Fatty Liver Disease |
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Gastroenterol. 2020 May 25. doi: 10.14309/ajg.0000000000000676. Online ahead of print.
Ramy Younes 1 2, Olivier Govaere 2, Salvatore Petta 3, Luca Miele 4 5, Dina Tiniakos 2, Alastair Burt 2, Ezio David 6, Fabio M Vecchio 4 7, Marco Maggioni 8, Daniela Cabibi 9, Anna L Fracanzani 10, Chiara Rosso 1, Maria J Garcia Blanco 11, Angelo Armandi 1, Gian Paolo Caviglia 1, Marco Y W Zaki 2 12, Antonio Liguori 4, Paolo Francione 10, Grazia Pennisi 3, Antonio Grieco 4 5, Luca Valenti 13, Quentin M Anstee 2 14, Elisabetta Bugianesi 1
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Author information
- 1Department of Medical Sciences, Division of Gastroenterology and Hepatology, A.O. Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
- 2The Newcastle Liver Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
- 3Sezione di Gastroenterologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy.
- 4Università Cattolica del Sacro Cuore, Rome, Italy.
- 5Area Medicina Interna, Gastroenterologia e Oncologia Medica, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
- 6Department of Pathology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, University of Turin, Turin, Italy.
- 7Area Anatomia Patologica, Fondazione Policlinico Gemelli IRCCS, Rome, Italy.
- 8Department of Pathology, Ca' Granda IRCCS Foundation, Milan, Italy.
- 9Pathology Institute, PROMISE, University of Palermo, Palermo, Italy.
- 10Unit of Medicine and Metabolic Disease, Department of Pathophysiology and Transplantation, Ca' Granda IRCCS Foundation, Policlinico Hospital, University of Milan, Milan, Italy.
- 11Hospital Universitario de La Princesa, Medicina Interna, Madrid, Spain.
- 12Biochemistry Department, Faculty of Pharmacy, Minia University, Minya, Egypt.
- 13Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS C'a Granda Ospedale Maggiore Policlinico, Milan, Italy.
- 14Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.
Abstract
Introduction: We investigated the longitudinal impact of antinuclear antibody (ANA) on clinical outcomes and survival in nonalcoholic fatty liver disease (NAFLD).
Methods: ANA were found in 16.9% of 923 biopsy-proven NAFLD patients, but none of them had histologic autoimmune hepatitis (AIH) or developed AIH after a mean follow-up of 106±50 months.
Results: Although ANA-positive cases had a higher prevalence of nonalcoholic steatohepatitis at baseline, the occurrence of liver-related events, hepatocellula carcinoma, cardiovascular events, extrahepatic malignancy, and overall survival were similar to ANA-negative.
Discussion: Once AIH has been ruled out, the long-term outcomes and survival are unaffected by the presence of ANA in patients with NAFLD.
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