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Management of Viral Hepatitis A, C, D and E in Pregnancy
Best Pract Res Clin Obstet Gynaecol 2020 Mar 21;S1521-6934(20)30050-X.
doi: 10.1016/j.bpobgyn.2020.03.009. Online ahead of print.
Mimi Tin-Yan Seto 1, Ka Wang Cheung 2, Ivan F N Hung 3
1Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China. Electronic address: email@example.com.
2Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China.
3Department of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Viral hepatitis can cause significant maternal and neonatal morbidity and mortality. Hepatitis A and E mainly present as acute hepatitis during pregnancy, while hepatitis C and D are usually found as chronic infection in pregnant women. Hepatitis A remains self-limiting during pregnancy while hepatitis E has a higher prevalence and manifests with a rigorous course in pregnant women. Screening of hepatitis C during pregnancy and its subsequent management during pregnancy are still a debatable topic. New treatments of hepatitis C and E require further evaluation for use in pregnancy. This review summarizes the prevalence, clinical manifestations, maternal, foetal and neonatal effects, and the management of hepatitis A, C, D and E viral infection during pregnancy.