1 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Recent studies have identified several pleiotropic effects of platelets on liver homeostasis and disease distinct from their long-recognized roles in hemostasis and coagulation. Concerns for bleeding have traditionally limited the use of anti-platelet agents in advanced liver disease. However, recent evidence increasingly suggests that pro-thrombotic tendencies may exceed the bleeding diathesis traditionally associated with advanced liver disease. This implies that anti-platelet therapy (APT) may in fact be safely used in certain patients with chronic liver disease.