1 UT Southwestern Medical Center, Dallas, TX.
Non-alcoholic fatty liver disease (NAFLD) is a spectrum that ranges from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. NAFLD is now the most common chronic liver disease in many developed countries. The latest Organ Procurement and Transplantation Network and Scientific Registry of Transplant Recipients (OPTN/SRTR) annual liver transplant report showed that hepatitis C (HCV) infection was no longer the most common indication for liver transplant; instead "other/unknown etiology" became the leading indication, and importantly, the highest number of transplants performed were for other/unknown liver diseases. The majority of cases categorized as other/unknown liver disease most likely represented NAFLD.