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Abstract Details
A Karnofsky performance status-based score predicts death after hospital discharge in patients with cirrhosis
Tandon P1, Reddy KR2, O'Leary JG3, Garcia-Tsao G4, Abraldes JG1, Wong F5, Biggins SW6, Maliakkal B7, Fallon MB8, Subramanian RM9, Thuluvath P10, Kamath PS11, Thacker LR12, Bajaj JS12; North American Consortium for the Study of End-Stage Liver Disease. Hepatology. 2017 Jan;65(1):217-224. doi: 10.1002/hep.28900. Epub 2016 Nov 29.
Author information
1University of Alberta, Edmonton, AB, Canada.
2University of Pennsylvania, Philadelphia, PA.
3Baylor University Medical Center, Dallas, TX.
4Yale University, New Haven, CT.
5University of Toronto, Toronto, ON, Canada.
6University of Colorado, Denver, CO.
7University of Rochester, Rochester, NY.
8University of Texas, Houston, TX.
9Emory University, Atlanta, GA.
10Mercy Medical Center, Baltimore, MD.
11Mayo Clinic, Rochester, MN.
12Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA.
Abstract
Identification of patients with cirrhosis at risk for death within 3 months of discharge from the hospital is essential to individualize postdischarge plans. The objective of the study was to identify an easy-to-use prognostic model based on the Karnofsky Performance Status (KPS). The North American Consortium for the Study of End-Stage Liver Disease consists of 16 tertiary-care hepatology centers that prospectively enroll nonelectively admitted cirrhosis patients. Patients enrolled had KPS assessed 1 week postdischarge. KPS was categorized into low (score 10-40), intermediate (50-70), and high (80-100). Of 954 middle-aged patients (57 ± 10 years, 63% men) with a median Model for End-Stage Liver Disease (MELD) score of 17 (interquartile range 13-21), the mortality rates for the low, intermediate, and high performance status groups were 23% (36/159), 11% (55/489), and 5% (15/306), respectively. Low, intermediate, and high performance status was seen in 17%, 51%, and 32% of the cohort, respectively. Low performance status was associated with older age, dialysis, hepatic encephalopathy, longer length of stay, and higher white blood cell count or MELD score at discharge. A model was derived using the three independent predictors of 3-month mortality: KPS, age, and MELD score. This score had better discrimination (area under the receiver operating characteristic curve = 0.74) than a model using MELD (area under the receiver operating characteristic curve = 0.62) or MELD and age (area under the receiver operating characteristic curve = 0.67) to predict 3-month mortality.
CONCLUSIONS:
Cirrhosis patients at risk for 3-month postdischarge mortality can be identified using a novel KPS-based score; this score may be adopted in practice to guide postdischarge early interventions, including the integrated provision of active and palliative management strategies.