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Abstract Details
Plasmapheresis as adjuvant therapy in Stevens-Johnson syndrome and hepatic encephalopathy
Hung PC, Wang HS, Hsia SH, Wong AM. Brain Dev. 2013 Jun 15. pii: S0387-7604(13)00174-5. doi: 10.1016/j.braindev.2013.05.010. [Epub ahead of print]
Source
Division of Pediatric Neurology, Chang Gung Children's Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: h2918@cgmh.org.tw.
Abstract
Stevens-Johnson syndrome (SJS) is a severe idiosyncratic reaction, most commonly triggered by medications, which is characterized by fever and mucocutaneous lesions, leading to necrosis and sloughing of the epidermis. Aside from skin and mucosal manifestations, SJS may also compromise heart, liver, kidney, lung, and gastrointestinal tract. Although cholestatic liver disease has been reported to occur in SJS, hepatic encephalopathy (HE) as a delayed complication has never been reported. We report a 4-year-old female child with anticonvulsant-induced SJS complicated by HE who was completely cured with a combination of systemic corticosteroid, intravenous immunoglobulin (IVIG), and plasmapheresis therapy. We suggested that plasmapheresis may be used as an adjuvant therapy for SJS with HE.