Author information

¹Beatty Liver and Obesity Research Program, Inova Health System, 3300 Gallows Road, Falls Church, VA, USA; Division of Rehabilitation, Kurume University Hospital, Kurume 830-0011, Japan; Department of Orthopedics, Kurume University School of Medicine, Kurume 830-0011, Japan.

²Beatty Liver and Obesity Research Program, Inova Health System, 3300 Gallows Road, Falls Church, VA, USA; The Global NASH Council, 2411 I Street, Washington DC, USA.

³College of Medicine, University of the Philippines, Manila, Philippines; The Global NASH Council, 2411 I Street, Washington DC, USA.

⁴Division of Rehabilitation, Kurume University Hospital, Kurume 830-0011, Japan; Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.

⁵Beatty Liver and Obesity Research Program, Inova Health System, 3300 Gallows Road, Falls Church, VA, USA; The Global NASH Council, 2411 I Street, Washington DC, USA. Electronic address: zobair.younossi@cldq.org.

Abstract

Alcohol-related liver disease and metabolic-dysfunction-associated steatotic liver disease are the most common causes of chronic liver disease. Globally, alcohol intake, and metabolic syndrome driven by excessive caloric intake and sedentary lifestyle have steadily increased over the past decades. Given the high prevalence rates of both excessive alcohol consumption and components of metabolic syndrome, both can frequently coexist in the same individuals and impact their lives. In this article, we review the impact of alcohol and metabolic syndrome on liver-related outcomes.