Author information

¹King's College Hospital NHS Foundation Trust, London, UK abid.suddle@nhs.net.

²Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.

³Department of Oncology, The Christie NHS Foundation Trust, Manchester, UK.

⁴Royal Free London NHS Foundation Trust, London, UK.

⁵University of Leeds, Leeds, UK.

⁶St James's University Hospital, Leeds, UK.

⁷Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

⁸Department of Pathology, University of Birmingham, Birmingham, UK.

⁹Division of Diagnostics and Therapies, University Hospitals Bristol NHS Trust, Bristol, UK.

¹⁰Royal Free Hospital, London, UK.

¹¹Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

¹²Department of Medical Physics and Biomedical Engineering, University College London, London, UK.

¹³Western Sussex Hospitals NHS Foundation Trust, Worthing, UK.

¹⁴King's College Hospital NHS Foundation Trust, London, UK.

¹⁵Department of Oncology, University College, London, UK.

Abstract

Deaths from the majority of cancers are falling globally, but the incidence and mortality from hepatocellular carcinoma (HCC) is increasing in the United Kingdom and in other Western countries. HCC is a highly fatal cancer, often diagnosed late, with an incidence to mortality ratio that approaches 1. Despite there being a number of treatment options, including those associated with good medium to long-term survival, 5-year survival from HCC in the UK remains below 20%. Sex, ethnicity and deprivation are important demographics for the incidence of, and/or survival from, HCC. These clinical practice guidelines will provide evidence-based advice for the assessment and management of patients with HCC. The clinical and scientific data underpinning the recommendations we make are summarised in detail. Much of the content will have broad relevance, but the treatment algorithms are based on therapies that are available in the UK and have regulatory approval for use in the National Health Service.