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Abstract Details
Unique Genetic Features of Lean NAFLD: A Review of Mechanisms and Clinical Implications
J Clin Transl Hepatol. 2024 Jan 28;12(1):70-78. doi: 10.14218/JCTH.2023.00252.Epub 2023 Aug 25.
1Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA.
2Division of Gastroenterology-Hepatology, University of Connecticut Health Center, Farmington, CT, USA.
Abstract
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the global population. About 20% have a normal body mass index (BMI) and a variant known as lean NAFLD. Unlike typical NAFLD cases associated with obesity and diabetes, lean NAFLD causes liver disease by mechanisms not related to excess weight or insulin resistance. Genetic disorders are among the major factors in developing lean NAFLD, and genome-wide association studies have identified several genes associated with the condition. This review aims to increase awareness by describing the genetic markers linked to NAFLD and the defects involved in developing lean NAFLD.
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