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Abstract Details
Low Performance of Hepatitis Delta Virus Testing Among Two National Cohorts of Chronic Hepatitis B Patients in the United States
Am J Gastroenterol. 2022 Aug 12. doi: 10.14309/ajg.0000000000001947. Online ahead of print.
1Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, CA, USA.
2Gastroenterology Section Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA.
3Quest Diagnostics, Secaucus, NJ.
4Center for Innovation to Implementation, Veterans Affairs Palo Alto Healthcare System, Menlo Park, CA, USA.
5Hepatitis B Foundation, Doylestown, PA, USA.
Abstract
Objective: To evaluate hepatitis delta virus (HDV) testing patterns among U.S. adults with CHB.
Methods: HDV testing was evaluated among CHB patients using Quest Diagnostics (2016-2020) and Veterans Affairs (VA) (2010-2020) data.
Results: Among 157,333 CHB patients (Quest), 6.7% received HDV testing, among which 2.2% were positive. HDV testing was higher in males, younger individuals, and in patients with advanced liver disease. Among 12,002 CHB patients (VA), 19.7% received HDV testing, among which 3.1% were positive. HDV testing was higher in younger individuals and Asians.
Conclusions: Low HDV testing was observed among two large U.S. cohorts of adults with CHB.