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Topic of the Month: Transient Elastography in Pediatric Liver Disease
J Pediatr Gastroenterol Nutr. 2021 May 11. doi: 10.1097/MPG.0000000000003168.Online ahead of print.
Anna M Banc-Husu1, Lee M Bass
1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Texas Children's Hospital, Baylor College of Medicine Division of Pediatric Gastroenterology, Hepatology and Nutrition, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine.
Transient elastography is an imaging technique utilizing shear wave technology to measure liver stiffness. Recent studies have shown success in utilizing this technique in children. Transient elastography is useful in estimating degree of fibrosis in various pediatric liver diseases, including biliary atresia, alpha-1-antitrypsin deficiency, Alagille syndrome, cystic fibrosis related liver disease, and NASH among others. However, confounding factors may affect elastography measurements such as obesity, severe inflammation, non-fasting state and hepatic congestion and should be considered when interpreting these measurements. Future studies will correlate liver stiffness on transient elastography and severity of disease.