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Abstract Details
Characteristics and Outcomes of Children With Cystic Fibrosis Hospitalized With Cirrhosis in the United States
Am J Gastroenterol. 2021 Apr 29. doi: 10.14309/ajg.0000000000001275. Online ahead of print.
Christina Thornton1, Ranjani Somayaji, Michael Parkins, Mark G Swain, Kathleen J Ramos, Christopher H Goss, Abdel A Shaheen
Author information
1Department of Medicine, Cumming School of Medicine, University of Calgary, Alberta, Canada; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Alberta, Canada; Department of Medicine, University of Washington, Seattle, Washington, USA.
Abstract
Introduction: To describe the characteristics and outcomes of children with cystic fibrosis (CF) hospitalized with cirrhosis in the United States.
Methods: We conducted a population-based cohort study of hospitalizations among children with CF using the 2016 Kid's Inpatient Database.
Results: In total, 9,615 admissions were analyzed. Diagnosis of cirrhosis was present in 509 (5.3%) and was significantly associated with increased mortality, length of stay, and hospital charges compared with those without cirrhosis. Hepatic encephalopathy was significantly associated with death in children with cirrhosis.
Discussion: Future interventions should be designed to support children with CF who have cirrhosis to improve clinical outcomes.
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