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Identification of hepatitis delta superinfection when investigating transaminitis in HIV/HBV coinfection
AIDS. 2021 May 10. doi: 10.1097/QAD.0000000000002940. Online ahead of print.
Ali Hamady1, Graham S Cooke, Lucy Jane Garvey
1Imperial College, London, UK Imperial College Healthcare NHS Trust, London UK.
Hepatitis delta (HDV) is a highly pathogenic virus which can cause rapidly progressive liver disease in individuals with chronic hepatitis B (HBV) and for which treatment options are limited. The incidence of sexually-transmitted HDV infection is unknown. Here we report the case of a HDV seronegative man with pre-existent HIV/HBV, taking effective tenofovir-containing ART, who experienced a significant acute transaminitis with HDV antibody seroconversion and viraemia and no other identifiable cause.