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Short Chain Fatty Acid and Fecal Microbiota Profiles Are Linked to Fibrosis in Primary Biliary Cholangitis
FEMS Microbiol Lett. 2021 Apr 9;fnab038. doi: 10.1093/femsle/fnab038. Online ahead of print.
Craig Lammert1, Andrea Shin1, Huiping Xu2, Christopher Hemmerich3, Thomas M O'Connell4, Naga Chalasani1
1Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
2Department of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
3Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN, USA.
4Department of Otolaryngology, Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
The gut microbiota and metabolome could play a role in primary biliary cholangitis (PBC) progression. We aimed to assess fecal microbiota and fecal short chain fatty acids (SCFA) in PBC according to fibrosis. In a cross-sectional study of 23 PBC patients, fecal microbiota and SCFAs were determined using 16S rRNA sequencing and nuclear magnetic resonance spectroscopy, respectively. Fecal acetate and SCFAs were higher in advanced fibrosis. Advanced fibrosis microbiota exhibited decreased alpha diversity, increased Weisella, and a distinct community composition. SCFAs correlated with individual taxa in non-advanced fibrosis. Fecal microbiota and SCFAs correspond with fibrosis in PBC.