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The Need for Consensus About Liver Transplantation For Patients With Neuropsychiatric Wilson's Disease
Prog Transplant. 2021 Mar 11;15269248211002806. doi: 10.1177/15269248211002806.Online ahead of print.
Alberto Ferrarese1, Patrizia Burra1
1Multivisceral Transplant Unit, Gastroenterology, Padua University Hospital, Padua, Italy.
Liver transplantation is considered an effective therapeutic option for Wilson's disease (WD) patients with hepatic phenotype, since it removes the inherited defects of copper metabolism, and is associated with excellent graft and patient outcomes. The role of liver transplantation in WD patients with mixed hepatic and neuropsychiatric phenotype has remained controversial over time, mainly because of high post-operative complications, reduced survival and a variable, unpredictable rate of neurological improvement. This article critically discusses the recently published data in this field, focussing in more detail on isolated neuropsychiatric phenotype as a potential indication for liver transplantation in WD patients.