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Abstract Details
Alagille syndrome and pregnancy
Obstet Med. 2021 Mar;14(1):39-41.doi: 10.1177/1753495X19849738.Epub 2019 Jun 9.
Adam Morton1, Sailesh Kumar2
Author information
1Obstetric Medicine and University of Queensland, Mater Health, Brisbane, Australia.
2School of Medicine and Mater Research Institute, University of Queensland, South Brisbane, Australia.
Abstract
Alagille syndrome is an autosomal dominant multisystem disorder with an estimated frequency of 1 in 30 000. Only a small number of pregnancy outcomes have been described in women with this condition. The report details the pregnancy outcomes of two women with Alagille syndrome. We also review the literature pertaining to this syndrome in pregnancy and demonstrate a significant risk of adverse pregnancy outcomes.