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Abstract Details
Virus spread in the liver: mechanisms, commonalities, and unanswered questions
Future Virol. 2020 Oct;15(10):707-715. doi: 10.2217/fvl-2020-0158.Epub 2020 Oct 27.
Alexi Tallan1, Zongdi Feng12
Author information
1Center for Vaccines & Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
2Department of Pediatrics, Ohio State University College of Medicine, Columbus OH 43210, USA.
Abstract
The liver is home to five known human hepatitis viruses (hepatitis A virus-hepatitis E virus). Despite being phylogenetically unrelated, these viruses replicate and spread in the liver without causing apparent cytopathic effects, and all have evolved strategies to counteract antibody-mediated inhibition of virus spread. In this review, we discuss the current understanding regarding the spread mechanisms for these viruses with an attempt to extract common principles and identify key questions for future studies.